Advances on the study of pathogenesis and treatment of alcohol-associated liver disease

LIANG Gaoshuang; PENG Jinying; LI Zhuan

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Journal of Hunan Normal University(Medical Science) ›› 2023, Vol. 20 ›› Issue (4) : 1-10.

Invited Review

Advances on the study of pathogenesis and treatment of alcohol-associated liver disease

LIANG Gaoshuang^*, PENG Jinying^*, LI Zhuan

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Abstract

Alcohol associated liver disease (ALD) has become a major cause of cirrhosis and liver failure across the world and its influence continues to increase. ALD encompasses a spectrum of diseases including asymptomatic liver steatosis, alcohol-associated hepatitis, alcohol associated fibrosis, cirrhosis, and even liver cancer. The progression of ALD involves in multiple cell types and even different organs including liver and gut. More importantly, there are very limited options for treatment of ALD currently due to the lack of effective diagnosis methods and clinical symptoms which resultes in patients with ALD are rarely diagnosed in the earlier phase of the disease spectrum. Therefore, it is of great strategic significance to deeply study the pathogenesis of ALD and clinical application value to develop effective diagnosis and treatment strategies. In present review, we discussed recent advances on the pathogenesis, current treatment options, and clinical trials of ALD.

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alcohol associated liver disease / pathogenesis / early diagnosis / treatment options

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LIANG Gaoshuang, PENG Jinying, LI Zhuan. Advances on the study of pathogenesis and treatment of alcohol-associated liver disease[J]. Journal of Hunan Normal University(Medical Science). 2023, 20(4): 1-10

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