Analysis of diagnostic value of endoscopic ultrasonography combined with serum 5-HIAA and SAA1 on patients with early gastric cancer

ZHOU Hongyan; HUANG Chunxia

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Journal of Hunan Normal University(Medical Science) ›› 2023, Vol. 20 ›› Issue (3) : 75-79.

Analysis of diagnostic value of endoscopic ultrasonography combined with serum 5-HIAA and SAA1 on patients with early gastric cancer

ZHOU Hongyan, HUANG Chunxia

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Abstract

Objective To study the value of endoscopic ultrasonography (EUS) combined with serum 5-hydroxyindole acetic acid (5-HIAA) and serum amyloid protein A1(SAA1) in the diagnosis of early gastric cancer (EGC) and its infiltration depth. Methods 111 patients with suspected EGC in the hospital between April 2019 and April 2021 were selected for the cross-sectional study. EUS examination was performed and serum 5-HIAA and SAA1 were measured. Patients were divided into EGC group and non-EGC group according to pathological results. Patients with EGC were classified as PT1a group and pT1b group according to the tumor infiltration depth. The EUS examination results and levels of serum 5-HIAA and SAA1 were compared between EGC group and non-EGC group and between pT1a group and pT1b group. Receiver operating characteristic (ROC) curve was used to analyze the application value of EUS examination and serum 5-HIAA and SAA1 in the diagnosis of EGC and EGC invading submucosa (SM). Results EUS examination showed 52 EGC positive cases, including 41 cases (77.36%) in EGC group and 11 cases (18.97%) in non-EGC group. The levels of serum 5-HIAA and SAA1 in EGC group were higher than those in non-EGC group (P<0.05). Among 53 patients with EGC, there were 34 cases in pT1a group and 19 cases in pT1b group, and EUS examination displayed 35 patients of M-layer tumor infiltration, including 28 cases (82.35%) in pT1a group and 7 cases (36.84%) in the pT1b group. And the levels of serum 5-HIAA and SAA1 in pT1a group were lower than those in pT1b group (P<0.05). The AUC values of EUS examination and serum 5-HIAA and SAA1 in diagnosing EGC were 0.783, 0.698 and 0.709 respectively, and the accuracy rates were 79.28%, 69.37% and 68.47% respectively, and the AUC and accuracy rate of the three combined diagnosis were 0.920 and 87.39%. The AUC values of EUS examination and serum 5-HIAA and SAA1 in diagnosing the EGC invading SM layer were 0.728, 0.678 and 0.690 respectively, and the accuracy rates were 75.47%, 71.69% and 66.04% respectively, and the AUC and accuracy rate of the three combined diagnosis were 0.847 and 71.69%. Conclusion EUS combined with serum 5-HIAA and SAA1 has a good reference value for EGC diagnosis and evaluation of infiltration depth, and is of great significance for early diagnosis and treatment of gastric cancer.

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early gastric cancer / endoscopic ultrasonography / 5-hydroxyindole acetic acid / serum amyloid protein A1 / diagnosis / infiltration depth

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ZHOU Hongyan, HUANG Chunxia. Analysis of diagnostic value of endoscopic ultrasonography combined with serum 5-HIAA and SAA1 on patients with early gastric cancer[J]. Journal of Hunan Normal University(Medical Science). 2023, 20(3): 75-79

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