Association between locus rs7044343 and rs3939286 of IL-33 gene polymorphisms and Kawasaki disease

HU Shuang; HE Qin; HU Yanan; HUANG Lihua; LI Zhuoying; YANG Zuocheng

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Journal of Hunan Normal University(Medical Science) ›› 2023, Vol. 20 ›› Issue (2) : 35-39.

Clinical Medicine

Association between locus rs7044343 and rs3939286 of IL-33 gene polymorphisms and Kawasaki disease

HU Shuang, HE Qin, HU Yanan, HUANG Lihua, LI Zhuoying, YANG Zuocheng

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Abstract

Objective To explore the relationship between polymorphism of rs7044343 and rs3939286 of IL-33 gene and Kawasaki disease (KD) and KD complicated with coronary artery lesion (CAL). Methods A total of 100 children with KD who were treated in the Department of Pediatrics of the Third Xiangya Hospital of Central South University from 2016 to 2021, and 100 healthy children with the same age at the same time were selected to detect the polymorphism of rs7044343 and rs3939286 of IL-33 gene by polymerase chain reaction (PCR). Results The frequency and genotype of IL-33 gene between Kawasaki disease group and healthy control group were almost equivalent. In Kawasaki disease group, there was no obvious difference between CAL group and non-CAL group. Conclusion The polymorphism of loci rs7044343 and rs3939286 in IL-33 gene has no significant correlation with Kawasaki disease and it complicated with coronary artery injury.

Key words

Kawasaki disease / IL-33 gene / polymorphisms / coronary artery lesion / children

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HU Shuang, HE Qin, HU Yanan, HUANG Lihua, LI Zhuoying, YANG Zuocheng. Association between locus rs7044343 and rs3939286 of IL-33 gene polymorphisms and Kawasaki disease[J]. Journal of Hunan Normal University(Medical Science). 2023, 20(2): 35-39

References

[1] Ae R, Makino N, Kuwabara M, et al.Incidence of Kawasaki Disease Before and After the COVID-19 Pandemic in Japan: Results of the 26th Nationwide Survey, 2019 to 2020[J]. JAMA Pediatr, 2022, 176(12): 1217-1224.
[2] Xie LP, Yan WL, Huang M, et al.Epidemiologic Features of Kawasaki Disease in Shanghai From 2013 Through 2017[J]. J Epidemiol, 2020, 30(10): 429-435.
[3] Ae R, Makino N, Kosami K, et al. Epidemiology, Treatments,Cardiac Complications in Patients with Kawasaki Disease: The Nationwide Survey in Japan, 2017-2018[J]. J Pediatr, 2020, 225: 23-29. e2.
[4] Sharma K, Vignesh P, Srivastava P, et al.Epigenetics in Kawasaki Disease[J]. Front Pediatr, 2021, 9: 673294.
[5] 周进, 谢圭, 罗叶萍, 等. 白细胞介素12A基因 rs568408 位点多态性与川崎病及其合并冠状动脉损伤的关联性研究[J]. 中国临床药理学杂志, 2020, 36(15): 2186-2188.
[6] 邹登, 阿莫, 江杰, 等. IL-1β基因-31T/C 多态性与川崎病的关联性[J]. 中南大学学报 (医学版), 2017, 42(1): 8-12.
[7] Dwyer GK, D'Cruz LM, Turnquist HR. Emerging Functions of IL-33 in Homeostasis and Immunity[J]. Annu Rev Immunol, 2022, 40: 15-43.
[8] Falahi S, Mortazavi SHR, Salari F, et al.Association between IL-33 Gene Polymorphism (Rs7044343) and Risk of Allergic Rhinitis[J]. Immunol Invest, 2022, 51(1): 29-39.
[9] López-mejías R, Genre F, Remuzgo-martínez S, et al. Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients[J]. PLoS One, 2015; 10(11): e0143153.
[10] 许波, 张莹莹. 川崎病患者治疗前后血清白介素-33、白介素-21变化及意义[J]. 实用医药杂志, 2016, 33(1): 36-37.
[11] 江载芳, 申昆玲, 沈颖. 诸福棠实用儿科学(第8版)[M]. 北京: 人民卫生出版社, 2015: 778-788.
[12] Gellis L, Castellanos DA, Oduor R, et al.Comparison of coronary artery measurements between echocardiograms and cardiac CT in Kawasaki disease patients with aneurysms[J]. J Cardiovasc Comput Tomogr, 2022, 16(1): 43-50.
[13] 申琳, 张驰, 贺勤, 等. 胸腺素β4基因rs955279位点多态性与川崎病的关联性研究[J]. 湖南师范大学学报 (医学版), 2022, 19(2): 12-15.
[14] Kim GB.Reality of Kawasaki disease epidemiology[J]. Korean J Pediatr, 2019, 62(8): 292-296.
[15] Hayashida K, Ae R, Masuda H, et al.Clinical Characteristics of Patients With Kawasaki Disease Whose Siblings Had the Same Disease[J]. Pediatr Infect Dis J, 2021, 40(6): 531-536.
[16] Jia C, Zhuge Y, Zhang S, et al.IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway[J]. Cell Death Dis, 2021, 12(6): 575.
[17] Schmitz J, Owyang A, Oldham E, et al.IL-33, an interleukin-1- like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines[J]. Immunity, 2005, 23(5): 479-490.
[18] 彭剑桥, 王宏波, 梁仙志, 等. 可溶性肿瘤发生抑制蛋白2和白细胞介素33联合检测在川崎病患儿心血管受损早期诊断中的应用[J]. 中国动脉硬化杂志, 2018, 26(10): 1016-1020.
[19] Li C, Mu R, Guo J, et al.Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis[J]. Arthritis Res Ther, 2014, 16(2): R105.