Mechanism on the Ginseng Lotion In the treatment of vaginitis Based on Network Pharmacology

LIU Xiaoting; JIANG Zhichao

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Journal of Hunan Normal University(Medical Science) ›› 2023, Vol. 20 ›› Issue (1) : 85-91.

Clinical Medicine

Mechanism on the Ginseng Lotion In the treatment of vaginitis Based on Network Pharmacology

LIU Xiaoting, JIANG Zhichao

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Abstract

Objective To explore the mechanism of Ginseng Lotion in the treatment of vaginitis by network pharmacology, so as to provide a theoretical basis for later experimental research. Methods The active ingredients and their targets of ginseng lotion Decoction were screened by the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), vaginitis targets were obtained using GeneCards database. The R language is used to obtain a target set for the treatment of vaginitis by Ginseng Lotion. The target set uses to construct “drug-disease-target” network and the Protein-Protein interaction (PPI) network to exPlore its mechanism. Finally, Functional enrichment analysis of gene ontology (GO) and Pathway enrichment analysis based on the Kyoto EncycloPedia of Genes and Genomes (KEGG) were Performed using R language. Results There were 112 active comPounds and 83 targets related to the treatment of vaginitis in Ginseng Lotion. The key targets involved RELA、MAPK3、MYC、HIF1A、MAPK1、TP53, etc. It mainly involves TNF signaling pathway, IL-17 signaling pathway, HIF-1 signaling pathway and PI3K-Akt signaling pathway to Play a theraPeutic role in stomach cancer. Conclusion Through network pharmacology methods, it is concluded that Ginseng Lotion can treat vaginitis through multi-component, multi-target and multi-pathway.

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Ginseng Lotion / vaginitis / network Pharmacology

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LIU Xiaoting, JIANG Zhichao. Mechanism on the Ginseng Lotion In the treatment of vaginitis Based on Network Pharmacology[J]. Journal of Hunan Normal University(Medical Science). 2023, 20(1): 85-91

References

[1] 朱迎萍. 清热化湿外洗方治疗湿热下注型阴道炎临床观察[J]. 光明中医, 2020, 35(20): 3147-3179.
[2] 金凤丽, 王佳, 杨席伟, 等. 细菌性阴道病患者阴道微生态及中西医研究进展[J]. 云南中医中药杂志, 2020, 41(10): 80-84.
[3] 何虹瑾, 吕梦奕, 王素霞. 中医药治疗阴道炎研究进展[J]. 浙江中西医结合杂志, 2022, 32(4): 387-390.
[4] 冯万喆, 闫平. 中西医诊治细菌性阴道病的研究进展[J]. 江西中医药, 2020, 51(9): 77-80.
[5] 刘文, 张广求, 谭璐, 等.参菊洗剂的研制及临床应用研究[Z].2015.
[6] 张广求, 张美祥, 谭璐. 参菊洗剂抗炎作用机制的研究[J]. 新疆医科大学学报, 2020, 43(9): 1236-1240.
[7] 马留璐. 参菊洗剂联合克霉唑栓治疗湿热型外阴阴道假丝酵母菌病的临床观察[D]. 兰州: 甘肃中医药大学, 2020.
[8] 刘文, 谭璐, 张广求, 等. 参菊洗剂治疗阴道炎的疗效观察[J]. 临床合理用药杂志, 2015, 8(26): 21-22.
[9] 张广求, 张美祥, 谭璐. 参菊洗剂抗炎作用机制的研究[J]. 新疆医科大学学报, 2020, 43(09): 1236-1240.
[10] 张广求, 张美祥, 谭璐. 参菊洗剂的抗过敏、止痒作用及急性毒性研究[J]. 中国药物应用与监测, 2020, 17(2): 81-85.
[11] 张广求. 参菊洗剂体外抗阴道毛滴虫作用[J]. 医药导报, 2016, 35(5): 458-460.
[12] Hopkins A L.Network pharmacology: the next paradigm in drug discovery[J]. Nat Chem Biol, 2008, 4(11): 682-690.
[13] Ru J, Li P, Wang J, et al.TCMSP: a database of systems pharmacology for drug discovery from herbal medicines[J]. J Cheminform, 2014, 6: 13.
[14] 吴勉华. 中医内科学(全国中医药行业高等教育“十四五”规划教材)[M]. 北京: 中国中医药出版社,2021: 283-284.
[15] 王琳, 李作孝. 黄芩素对实验性自身免疫性脑脊髓炎小鼠的影响及机制研究[J]. 天津医药, 2022, 50(4): 381-387.
[16] Luo X, Yu Z, Chao D, et al.Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice[J]. Sci Rep, 2017, 7(1): 16374.
[17] Young J K, Hyun J K, Ji L, et al.Anti-Inflammatory Effect of Baicalein on Polyinosinic-Polycytidylic Acid-Induced RAW 264.7 Mouse Macrophages[J]. Viruses, 2018, 10(5): 224.
[18] Mu Y, Zeng H, Chen W.Quercetin Inhibits Biofilm Formation by Decreasing the Production of EPS and Altering the Composition of EPS in Staphylococcus epidermidis[J]. Fron Microbiol, 2021, 12: 631058.
[19] Aygü L A, Öztürk İ, Çilli F F, et al.Quercetin inhibits swarming motility and activates biofilm production of Proteus mirabilis possibly by interacting with central regulators, metabolic status or active pump proteins[J]. Phytomedicine, 2019, 57: 65-71.
[20] 贾硕, 张帆, 周寰, 等. 食源性甾醇类化合物生物活性及应用[J]. 食品工业科技, 2019, 40(08): 310-316.
[21] Ding K, Tan Y, Ding Y, et al.β‐Sitosterol improves experimental colitis in mice with a target against pathogenic bacteria[J]. J Cell Biochem, 2019, 12(4): 5687-5694.
[22] Kim SJ, Park H, Kim HP.Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: structure-activity relationship and action mechanism[J]. Arch Pharm Res, 2004, 27(9): 937-943.
[23] 唐宁, 李子艳, 周咏梅, 等. 木樨草素抗炎作用机制的初步探讨[J]. 中国临床药理学与治疗学, 2007, 12(2): 195-199.
[24] 吴小磊, 钟晨, 史金铭. 鞣花酸的生物学效应[J]. 中国林副特产, 2019(1): 73-78.
[25] Rogerio AP, Fontanari C, Boorducchi E, et al.Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma[J]. Eur J Pharmacol, 2008, 580(1-2): 262-270.
[26] 郭小华, 朱燕亮, 吴龙火. 淫羊藿中抗骨关节炎成分的分子对接研究[J]. 赣南医学院学报, 2021, 41(1): 11-16.
[27] Shen H, Na W, Yu W, et al.JNK Inhibitor SP600125 Attenuates Paraquat-Induced Acute Lung Injury: an In Vivo and In Vitro Study[J]. Inflammation, 2017, 40(4): 1319-1330.
[28] 孙昌瑞, 冯林, 邓君, 等. 四种乳腺癌相关基因联合检测对乳腺癌诊断的临床应用研究[J]. 现代肿瘤医学, 2013, 21(12): 2726-2728.
[29] 祝葆华, 陈孝文, 唐德燊, 等. c-myc与Bcl-2在大鼠抗Thy1.1系膜增生性肾炎肾小球内的表达[J]. 现代中西医结合杂志, 2001, 10(16): 1520-1522.
[30] 于传宗, 张凤兰, 慕宗杰, 等. 野生蒙古口蘑多糖通过STAT3和HIF-1α通路对LPS诱导的巨噬细胞发挥抗炎调节作用[J]. 食品与生物技术学报, 2020, 39(6): 93-98.
[31] 王永云, 靳文, 俞兰. 胃癌相关基因及靶向治疗的研究进展[J]. 医学综述, 2020, 26(19): 3814-3819.