Objective To study the curative effect of different regimens on diabetic peripheral neuropathy (DPN). Methods 96 cases ofpatients with DPN treated in our hospital fromOctober 2015 to February 2017 were selected as study subjects, andthey were divided into A, B and C three groups by random number table method, with 32 cases in each group. Group A were treated with mecobalamin on the basis of routine treatment. Based on the treatment for group A, group B were additionally treated with αlipoic acid, and group D were additionally treated with Mudan granules and α lipoic acid. The blood glucose, blood lipids, vibration sense, pressure sense, temperature sense, ankle jerk, symptom score and adverse reactions were compared among the three groups before treatment and after 10 days of treatment. Results After 10daysof treatment, the vibration perceptionthresholds (VPT) of left and right lower limbs of group C ［ (15.24±2.95) V, (15.07±2.75) V］ were significantly lower than those of group A and group B, while VPT of left and right lower limbs of group B ［ (17.39±3.63) V, (17.11±3.21) V］ were significantly lower than those of group A ［ (19.62±3.14) V, (19.35±2.87) V］. The abnormal rates of ankle jerkin group B and group C after 10 days of treatment (18.8% and 15.6%) were significantly lower than that in group A (43.8%). Conclusion Mudan granules combined with α lipoic acid and mecobalamin can promote the repair of damaged nerve tissues andrelieve symptoms of DPN.