Objective To compare the effects of bridge combined internal fixation and locking compression plate fixation in the treatment of limb fractures. Methods A total of 70 patients with limb fractures were selected from January 2015 to July 2016 in our Hospital. The patients were randomly divided into the observation group and the control group with 35 cases in each group: The observation group was treated with bridging combined internal fixation and the control group was given locking compression plate internal fixation. After 6 months of follow-up, the general operation data between the two groups were compared and the Constant shoulder score, and Hss knee score, visual analogue scale (VAS) were used to assess application of the function and pain degree of shoulder and elbow joint between the two groups. And the quality of life was analyzed by the short form health survey (SF-36) and the postoperative complications were observed. Results The operative time and fracture healing time were shorter in the observation group than those in the control group. The Constant score and the Hss score of the two groups after operation were increased significantly compared with the preoperative group, but there was no significant difference between the two groups. The VAS score (2.17±0.25) in the observation group was significantly higher than that in the control group. The physiological and psychological scores and total score (88.34±1.67) of SF-36 in the 6 months after the operation were significantly higher in the observation group than those in the control group. The incidence rate of complications was 5.71% in the observation group at 6 months follow-up, which was lower than that in the control group with 22.86%. Conclusion Compared with locking compression plate internal fixation, bridging combined with internal fixation is better for the treatment of limb fractures and can significantly shorten the operation time, fracture healing time, and produce less intraoperative blood loss, low postoperative complications rate, and significantly improve patients quality of life, therefore it is worth clinical application.