Objective To observe the effect of chronic intermittent hypoxia and reoxygenation on hypoglossal nerve activity
in rat. Methods 30 male SD rats were randomly divided into five groups: intermittent hypoxia 4 weeks group (IH4 group),
intermittent hypoxia 8 weeks group (IH8 group), intermittent hypoxia 12 weeks group (IH12 group), reoxygenation group (RH
group),unhandled control group(UC group). After the start of the experiment, in twelfth weeks, hypoglossal motor output was
measured. Results Comparison with control rats, hypoglossal nerve activity was increased in IH4, IH8, IH12 rats .Comparison
with IH4 ,IH8 rats , IH12 rat hypoglossal nerve activity was significantly decreased, but still higher than control group. hypoglossal
nerve burst frequency and amplitude in group RH than IH4, IH8, IH12 groups were significantly decreased. Compared
with the control group, no statistical significance. Conclusion Long-term stimulation of CIH evoke sustained augmentation
of hypoglossal nerve activity and then decreased . In timely reoxygenation restored the post-hypoxia hypoglossal nerve burst
frequency and amplitude decline in CIH rats.
Key words
Chronic intermittent hypoxia /
Obstructive Sleep Apnea-Hypopnea Syndrome /
Hypoglossal Nerve Discharge /
Rat
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