目的 探讨血清镁水平与新生儿细菌感染性黄疸的相关性及其在新生儿细菌感染性黄疸中的临床意义。方法 选取2022年5月至2025年5月于本院确诊黄疸的新生儿136例为研究对象,根据病原学检查分为非感染性黄疸组（n=84）和感染性黄疸组（n=52）,收集患者临床资料进行单因素分析、受试者工作特征曲线（ROC）评估血清镁预测价值以及Pearson相关性分析。结果 感染性黄疸组在黄疸消退时间>5 d占比、肝功能损伤占比、病情严重程度中度和重度占比、血清镁、CRP、PCT和TcB水平均显著高于非感染性黄疸组,血清镁具有较好的预测新生儿发生细菌感染性黄疸的价值（AUC=0.801,P<0.05）。新生儿黄疸中,高血清镁组在黄疸消退时间>5 d占比、CRP、PCT和TcB水平均显著高于低血清镁组,且CRP、PCT和TcB水平与血清镁水平均呈显著正相关;而在新生儿细菌感染性黄疸中,高血清镁组在病情严重程度中度和重度占比、CRP、PCT和TcB水平均显著高于低血清镁组,仅有CRP和PCT与血清镁水平均呈显著正相关。结论 感染性黄疸患儿黄疸消退时间延长、肝功能损伤及病情严重程度加重且血清镁、CRP、PCT和TcB水平升高;其中血清镁具有良好的预测价值,且与新生儿细菌感染性黄疸的CRP和PCT水平具有正相关关系。本研究结果能在一定程度上为临床实践开发早期预防、诊断的无创工具提供参考。
Abstract
Objective To investigate the correlation between serum magnesium levels and neonatal bacteria infectious jaundice and its clinical significance in this condition. Methods A total of 136 neonates diagnosed with jaundice at our hospital from May 2022 to May 2025 were enrolled and divided into the non-infectious jaundice group (n=84) and the infectious jaundice group (n=52) based on etiological examinations. Clinical data were collected for univariate analysis, receiver operating characteristic (ROC) curve analysis to evaluate the predictive value of serum magnesium, and Pearson correlation analysis. Results The infectious jaundice group had significantly higher proportions of jaundice resolution time>5 days, liver function injury, moderate and severe disease severity, and levels of serum magnesium, CRP, PCT, and TcB than the non-infectious jaundice group. Serum magnesium showed good predictive value for neonatal bacteria infectious jaundice (AUC=0.801, P<0.05). In neonatal bacteria jaundice, the high-serum-magnesium group had significantly higher proportions of jaundice resolution time>5 days and levels of CRP, PCT, and TcB than the low-serum-magnesium group, and CRP, PCT, and TcB levels were significantly positively correlated with serum magnesium levels. In neonatal infectious jaundice, the high-serum-magnesium group had significantly higher proportions of moderate and severe disease severity and levels of CRP, PCT, and TcB than the low-serum-magnesium group, and only CRP and PCT levels were significantly positively correlated with serum magnesium levels. Conclusion Infants with infectious jaundice have prolonged jaundice resolution time, liver function injury, increased disease severity, and elevated levels of serum magnesium, CRP, PCT, and TcB. Among them, serum magnesium has good predictive value and is positively correlated with CRP and PCT levels in neonatal bacteria infectious jaundice. The results of this study can, to a certain extent, provide a reference for developing early prevention and non-invasive diagnostic tools in clinical practice.
关键词
感染性黄疸 /
新生儿 /
血清镁 /
临床意义
Key words
infectious jaundice /
neonate /
serum magnesium /
clinical significance
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基金
河北省2023年度医学科学研究课题“NLRP3、TLR4在新生儿重症肺炎合并呼吸衰竭患者中的表达及预后评估的意义”（20231980）
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