目的：探讨外周血辅助性T细胞17（Th17）/调节性T细胞（Treg）相关细胞因子在卵巢癌中的预后评估价值。方法：选取2018年7月―2020年6月广西桂林医学院第二附属医院收治的80例卵巢癌患者作为卵巢癌组,选取同期体检健康者50例为健康组;统计卵巢癌组患者随访3年内预后情况,复发、死亡为预后不良,无复发、生存者为预后良好。检测各组外周血Th17、Treg细胞百分率、白细胞介素（IL）-17与IL-10水平,计算Th17/Treg;比较卵巢癌组、健康组以及不同临床分期卵巢癌患者上述指标差异。采用Cox回归分析明确相关危险因素,并绘制ROC曲线验证Th17/Treg与IL-17、IL-10对卵巢癌预后的预测效能。结果：卵巢癌组患者外周血Th17、Treg细胞占比、Th17/Treg以及IL-17、IL-10水平均高于健康组患者。Ⅰ~Ⅱ期患者外周血Th17、Treg细胞占比、Th17/Treg以及IL-17、IL-10水平均低于Ⅲ~Ⅳ期患者。预后不良患者与预后良好患者比较,年龄、临床分期、残余病变大小、接受化疗疗程数、Th17、Treg、Th17/Treg、IL-17、IL-10差异具有统计学意义。多因素Cox回归分析结果显示,临床分期、残余病变大小、接受化疗疗程数、外周血Th17、Treg比例、Th17/Treg、IL-17、IL-10水平为卵巢癌患者预后的独立影响因素。ROC曲线结果显示,Th17/Treg、IL-17、IL-10及3项联合的ROC曲线下面积（AUC）分别为0.789、0.845、0.839、0.960。结论：Th17/Treg及其相关细胞因子如IL-17、IL-10水平的变化可能参与卵巢癌的发生与发展,并与患者预后情况密切相关,对预后具有一定的预测价值。

Objective To investigate the prognostic value of peripheral blood helper T cell 17（Th17）/ regulatory T cell（Treg）- related cytokines in ovarian cancer. Methods A total of 80 patients with ovarian cancer admitted to the Second Affiliated Hospital of Guangxi Guilin Medical College from July 2019 to June 2021 were selected as the ovarian cancer group，and 50 healthy patients in the same period were selected as the healthy group. The prognosis of ovarian cancer patients during 3 years follow-up was analyzed. Recurrence and death were poor prognosis，while no recurrence and survivors were good prognosis. The percentage of Th17，Treg cells，interleukin-17（IL-17）and IL-10 in peripheral blood of each group were detected，and Th17/Treg was calculated. The above indexes were compared between ovarian cancer group，healthy group and ovarian cancer patients with different clinical stages. Cox regression analysis was used to identify related risk factors，and ROC curves were drawn to verify the prognostic efficacy of Th17/Treg，IL-17 and IL-10 in ovarian cancer. Results The proportion of Th17 and Treg cells，Th17/Treg and IL-17 and IL-10 levels in peripheral blood of patients with ovarian cancer group were higher than those in healthy group. The proportion of Th17 and Treg cells，Th17/Treg and IL-17 and IL-10 levels in peripheral blood of patients with stage Ⅰ to Ⅱ were lower than those of patients with stage Ⅲ to Ⅳ. There were statistically significant differences in age，clinical stage，residual lesion size，number of chemotherapy courses，Th17，Treg，Th17/Treg，IL-17 and IL-10 between patients with poor prognosis and those with good prognosis. Multivariate Cox regression analysis showed that clinical stage，residual lesion size，number of chemotherapy courses，Th17，Treg ratio in peripheral blood，Th17/Treg，IL-17 and IL-10 levels were independent prognostic factors of ovarian cancer patients. ROC curve results showed that the area under ROC curve（AUC）of Th17/Treg，IL-17，IL-10 and the three combinations were 0.789，0.845，0.839 and 0.960，respectively. Conclusion The changes of Th17 / Treg and its related cytokines，such as IL-17 and IL-10，may participate in the occurrence and development of ovarian cancer，and are closely related to the prognosis of patients，which has a certain predictive value for prognosis.