酒精相关性肝病致病机制与诊疗研究进展

梁高爽; 彭金英; 李专

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湖南师范大学学报医学版 ›› 2023, Vol. 20 ›› Issue (4) : 1-10.

特邀综述

酒精相关性肝病致病机制与诊疗研究进展

梁高爽^*, 彭金英^*, 李专

作者信息 +

Advances on the study of pathogenesis and treatment of alcohol-associated liver disease

LIANG Gaoshuang^*, PENG Jinying^*, LI Zhuan

Author information +

文章历史 +

摘要

酒精性肝病（alcohol associated liver disease,ALD）是肝脏相关死亡的主要原因,且发病率逐年上升,已成为危害人民健康的慢性疾病之一。ALD包括脂肪肝、酒精性肝炎、酒精性肝硬化甚至肝癌等病理类型。ALD致病因素尚不明确,涉及多种细胞甚至器官的相互作用。ALD机制复杂,涉及肝细胞损伤、炎症反应、肠道通透性与微生物改变等。早期治疗可逆转患者病情,但早期诊断手段十分有限,难以在早期发现病情并及时干预。因此,深入研究ALD致病机制,开发更有效的诊断和治疗手段具有临床应用价值。本文综述了ALD相关的致病机制与诊断治疗研究进展,以期为后续研究ALD致病机制与诊疗药物研发提供参考。

Abstract

Alcohol associated liver disease (ALD) has become a major cause of cirrhosis and liver failure across the world and its influence continues to increase. ALD encompasses a spectrum of diseases including asymptomatic liver steatosis, alcohol-associated hepatitis, alcohol associated fibrosis, cirrhosis, and even liver cancer. The progression of ALD involves in multiple cell types and even different organs including liver and gut. More importantly, there are very limited options for treatment of ALD currently due to the lack of effective diagnosis methods and clinical symptoms which resultes in patients with ALD are rarely diagnosed in the earlier phase of the disease spectrum. Therefore, it is of great strategic significance to deeply study the pathogenesis of ALD and clinical application value to develop effective diagnosis and treatment strategies. In present review, we discussed recent advances on the pathogenesis, current treatment options, and clinical trials of ALD.

导出引用

梁高爽, 彭金英, 李专. 酒精相关性肝病致病机制与诊疗研究进展[J]. 湖南师范大学学报医学版. 2023, 20(4): 1-10

LIANG Gaoshuang, PENG Jinying, LI Zhuan. Advances on the study of pathogenesis and treatment of alcohol-associated liver disease[J]. Journal of Hunan Normal University(Medical Science). 2023, 20(4): 1-10

中图分类号： R575

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