目的：研究不同方案治疗糖尿病周围神¾病变的疗效。方法：选取我院2015年10月~2017年2月96例糖尿病周围神¾病变患者为研究对象，将纳入患者按随机数表法分为A组、B组、C组，每组32例。A组在常规治疗基础上加用甲钴胺，B组在A组基础上加用α-硫辛酸，C组在A组基础上加用木丹颗粒与α-硫辛酸。比较三组治疗前与治疗10d后血糖、血脂、振动觉、压力觉、温度觉、踝反射、症状评分、不良反应。结果：C组治疗10d后左侧下肢与右侧下肢感觉振动阈值（VPT）分别为（15.24±2.95）V、（15.07±2.75）V显著低于A组与B组，B组左侧下肢与右侧下肢VPT分别为（17.39±3.63）V、（17.11±3.21）V显著低于A组的（19.62±3.14）V、（19.35±2.87）V。B组与C组治疗10d踝反射异常率分别为18.8%、15.6%显著低于A组的43.8%。结论：木丹颗粒联合α-硫辛酸、甲钴胺可以促进受损神¾组织修复，在改善糖尿病周围神¾病变症状方面具有一定优势。

Objective To study the curative effect of different regimens on diabetic peripheral neuropathy (DPN). Methods 96 cases ofpatients with DPN treated in our hospital fromOctober 2015 to February 2017 were selected as study subjects, andthey were divided into A, B and C three groups by random number table method, with 32 cases in each group. Group A were treated with mecobalamin on the basis of routine treatment. Based on the treatment for group A, group B were additionally treated with αlipoic acid, and group D were additionally treated with Mudan granules and α lipoic acid. The blood glucose, blood lipids, vibration sense, pressure sense, temperature sense, ankle jerk, symptom score and adverse reactions were compared among the three groups before treatment and after 10 days of treatment. Results After 10daysof treatment, the vibration perceptionthresholds (VPT) of left and right lower limbs of group C ［ (15.24±2.95) V, (15.07±2.75) V］ were significantly lower than those of group A and group B, while VPT of left and right lower limbs of group B ［ (17.39±3.63) V, (17.11±3.21) V］ were significantly lower than those of group A ［ (19.62±3.14) V, (19.35±2.87) V］. The abnormal rates of ankle jerkin group B and group C after 10 days of treatment (18.8% and 15.6%) were significantly lower than that in group A (43.8%). Conclusion Mudan granules combined with α lipoic acid and mecobalamin can promote the repair of damaged nerve tissues andrelieve symptoms of DPN.