目的：观察胰激肽原酶片辅助乌司他丁治疗对急性胰腺炎患者微循环障碍的影响。方法：100例急性胰腺炎患者按随机数字表法将患者分为观察组和对照组，每组50例，对照组患者给予乌司他丁注射液10万单位+5%葡萄糖注射液，观察组患者在对照组基础上加用胰激肽原酶片，治疗2周，观察比较两组患者临床疗效，治疗前后血清中TNF-α、PFA、IL-6、IL-10水平，全血高切粘度、全血低切粘度、血浆粘度、血沉等血液流变学指标及凝血酶时间（TT）、凝血酶Ô时间（PT）、部分活化凝血酶时间（APTT）、D-二聚体等凝血功能指标和不良反应发生情况。结果：观察组患者治疗总有效率（94.0%）显著高于对照组（76.0%），治疗后两组患者TNF-α、PFA、IL-6、IL-10表达水平较治疗前均显著降低，且观察组患者TNF-α、PAF、IL-6、IL-10表达水平显著低于对照组，治疗后两组患者全血高切粘度、全血低切粘度、血浆粘度、血沉指标较治疗前均显著降低，且观察组患者血液流变学指标显著低于对照组。治疗后两组患者凝血功能指标TT、PT、APTT、D-二聚体较治疗前显著延长，且与对照组比较，观察组患者凝血功能指标显著延长。两组患者不良反应发生率比较，差异不具有统计学意义。结论：胰激肽Ô酶片辅助乌司他丁能够有效改善急性胰腺炎患者临床症状，能够通过扩张血管降低炎症因子水平及凝血功能来改善患者微Ñ环障°，且不增加患者不良反应，值得临床推广使用。

Objective To observe the effect of pancreatic kininogenase tablets assisted with ulinastatin on microcirculation disorder in patients with acute pancreatitis. Methods 100 cases of patients with acute pancreatitis were randomly divided into the observation group and the control group according to the random number table method, with 50 cases in each group. The patients in the control group were treated with ulinastatin injection of 100, 000 units plus 5% glucose injection and the patients in the observation group were given pancreatic kininogenase on the basis of treatment in the control group, and the course of treatment was 2 weeks. The clinical efficacy of the two groups, the levels of TNF-α, PFA, IL-6, IL-10, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, erythrocyte sedimentation and other hemorheological indexes, thrombin time (TT), prothrombin time (PT), partial activated thrombin time (APTT), D-dimer and other coagulation function and the occurrence of adverse reactions were observed and compared between the two groups before and after treatment. Results The total effective rate of the observation group (94%) was significantly higher than that of the control group (76%). The expression levels of TNF-α, PFA, IL-6 and IL-10 in the two groups were significantly lower than those before treatment, and the expression levels of TNF-α, PAF, IL-6 and IL-10 in the observation group were significantly lower than those in the control group. After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and erythrocyte sedimentation indexes were significantly lower than those before treatment, and the hemorheological indexes of the observation group were significantly lower than those in the control group. The coagulation function indexes of TT, PT, APTT and D-dimer in the two groups were significantly longer than those in the control group, and the coagulation function indexes of the observation group was significantly longer than those of the control group. There was no significant difference in the incidence rate of adverse reactions between the two groups. Conclusion Pancreatic kininogenase tables assisted with ulinastatin can effectively improve the clinical symptoms of patients with acute pancreatitis, can dilate the blood vessels by reducing the levels of inflammatory factors and coagulation function to improve microcirculation disorder without increasing the adverse reactions. Therefore it is worthy of clinical promotion and application.