目的：探究超声检查联合hs-CRP及CA125检测在诊断子宫内膜癌上的临床应用。方法：选择107例子宫内膜癌患者作为研究对象，按照FIGO分期标准分为Ⅰ~Ⅱ期58例、 Ⅲ～Ⅳ期49例。就不同分期患者的血清hs-CRP、CA125水平及阳性率进行比较，采用ROC曲线对超声检查联合hs-CRP、CA125检测子宫内膜癌的诊断能力进行评价。结果：Ⅰ~Ⅱ期子宫内膜癌患者的hs-CRP以及CA125水平均显著低于 Ⅲ~Ⅳ期子宫内膜癌患者，且FIGO分期与其hs-CRP及CA125水平呈现正相关，差异比较有统计学意义。Ⅰ~Ⅱ期子宫内膜癌患者的hs-CRP阳性率、CA125阳性率以及hs-CRP与CA125阳性率均显著低于Ⅲ~Ⅳ期子宫内膜癌患者，差异有统计学意义。超声联合hs-CRP、CA125的线下面积、敏感度及特异度明显大于超声联合hs-CRP、超声联合CA125。结论：借助经阴道超声检查能够发现可疑子宫内膜癌的病灶，辅以血清hs-CRP以及CA125检测，有助于子宫内膜癌的及早诊断，能够显著提高子宫内膜癌的临床检出率，从而减少了漏诊、误诊的情况发生。

Objective To research the clinical application of ultrasonography combined with the detection of hs-CRP and CA125 in the diagnosis of endometrial cancer. Method 107 cases of endometrial carcinoma in our hospital were selected as the research objects. According to the FIGO staging criteria, they were divided into the stage Ⅰ~Ⅱ (58 cases) and the stageⅢ~Ⅳ (49 cases). The levels of serum hs-CRP, CA125 and the positive rate in different stages were compared. The diagnostic ability of ultrasonography combined with hs-CRP and CA125 in endometrial carcinoma were evaluated by ROC curve. Result The levels of hs-CRP and CA125 in patients with stage Ⅰ~Ⅱ were significantly lower than those of stage Ⅲ~Ⅳ, the FIGO staging was positively correlated with the levels of hs-CRP and CA125, and the differences were statistically significant. The positive rate of hs-CRP, CA125 and hs-CRP combined with CA125 in patients with stage Ⅰ~Ⅱ were were significantly lower than that those in stage Ⅲ~Ⅳ, the differences were statistically significant. The sensitivity and specificity of ultrasound combined with hs-CRP and CA125 was significantly greater than that of ultrasound combined with hs-CRP and ultrasound combined with CA125. Conclusion Transvaginal ultrasound can detect suspicious endometrial cancer lesions. Combined detection of serum hs-CRP and CA125 can helpful for the early diagnosis of endometrial cancer, and can significantly improve the clinical detection rate of endometrial cancer, thereby reducing the misdiagnosis and misdiagnosis.