抗氧化疗法对急性心肌梗死患者的长期疗效研究

王传杰; 于爱东; 岳海静; 等

PDF(1948 KB)

湖南师范大学学报医学版 ›› 2018, Vol. 15 ›› Issue (3) : 126-128.

临床医学

抗氧化疗法对急性心肌梗死患者的长期疗效研究

王传杰，于爱东，岳海静，邢佳丽

作者信息 +

Long - term efficacy of antioxygen therapy in patients with acute myocardial infarction

Wang Chuan-jie, Yu Ai-dong, Yue Hai-jing, Xing Jia-li

Author information +

文章历史 +

摘要

目的：探究抗氧化疗法对急性心肌梗死患者的长期疗效。方法：选取2015年9月~2016年11月104例在我院接受治疗的急性心肌梗死患者为研究对象，按随机数表法将患者分为观察组和对照组，对照组采用常规冠心病二级预防治疗，观察组在对照组的基础上服用普罗布考抗氧化治疗，比较两组患者治疗1年后的血脂水平、MDA、SOD含量、hs-CRP、NO及ox-LDL水平，并对患者心脏扩大率进行比较。结果：观察组治疗后MDA、SOD水平分别为（5.47±1.18）μmol/mL、（154.93±29.57）U/L，对照组分别为（7.31±1.90）μmol/mL、（103.25±27.62）U/L，差异具有统计学意义；观察组TC、TG、LDL-C水平低于对照组，HDL-C水平高于对照组；观察组治疗后NO及ox-LDL水平分别为（63.51±10.70）μmol/L、（391.64±37.28）μg/L，对照组分别为（48.28±11.78）μmol/L、（487.64±40.27）μg/L；1年后复查结果显示，观察组心脏扩大率为7.69%，低于对照组的34.62%，差异具有统计学意义。结论：抗氧化疗法能有效抑制氧化应激反应，在治疗急性心肌梗死中疗效显著，值得临床推广应用。

Abstract

Objective To investigate the long-term efficacy of anti-oxidative therapy in patients with acute myocardial infarction. Methods A total of 104 acute myocardial infarction patients treated in our hospital from September 2015 to November 2016 were selected as study subjects. Patients were divided into observation group and control group according to random number table method. The control group received routine coronary heart disease II Grade prevention and treatment. The observation group was treated with probucol anti-oxidant therapy on the basis of the control group. The levels of blood lipid, MDA, SOD, hs-CRP, NO and ox-LDL in the two groups were compared. Results The levels of MDA and SOD in the observation group were (5.47±1.18)μmol / ml and (154.93±29.57) U / L, respectively, and those in the control group were 7.31±1.90μmol / ml and 103.25±27.62 U / . The levels of TC, TG and LDL-C in the observation group were lower than those in the control group, and the levels of HDL-C in the observation group were higher than those in the control group The levels of LDL were (63.51±10.70)μmol / L and (391.64 ± 37.28)μg / L respectively in the control group and (48.28±11.78)μmol / L and 487.64±40.27μg / L respectively, with statistical significance. Conclusion Antioxidant therapy can effectively inhibit oxidative stress and has a significant therapeutic effect in the treatment of acute myocardial infarction. It is worthy of clinical application.

关键词

/ font-family: 宋体 / mso-spacerun: 'yes' / mso-font-kerning: 1.0000pt">抗氧化疗法 / 急性心肌梗死 / 普罗布考 / 疗效 / font-family: 宋体 / mso-spacerun: 'yes' / mso-font-kerning: 1.0000pt"> / /

Key words

anti-oxidative therapy

/ acute myocardial infarction / probucol / efficacy

引用本文

EndNote

Ris (Procite)

Bibtex

导出引用

王传杰，于爱东，岳海静，等.

抗氧化疗法对急性心肌梗死患者的长期疗效研究

[J]. 湖南师范大学学报医学版. 2018, 15(3): 126-128

Wang Chuan-jie, Yu Ai-dong, Yue Hai-jing,et al.

Long - term efficacy of antioxygen therapy in patients with acute myocardial infarction

[J]. Journal of Hunan Normal University(Medical Science). 2018, 15(3): 126-128

参考文献

［1］张名扬, 吕肖锋, 张微微, 等.2型糖尿病合并急性脑梗死患者血糖波动对体内氧化应激水平的影响及意义［J］. 中国全科医学, 2014, 17(7): 784-787.

［2］付志, 胡海英, 郑明空, 等. 血必净注射液治疗急性非ST段抬高型心肌梗死的临床观察［J］. 中国药房, 2017, 28(23): 3257-3261.

［3］张颖. 急性脑梗死患者急性期血清OPN、氧化应激水平的变化及其与神经损伤和预后的关系［J］. 广东医学, 2017, 38(9): 1386-1389.

［4］刘大朋, 毛静. 丹参酮ⅡA磺酸钠对心肌梗死患者溶栓治疗后心肌氧化应激损伤的保护作用研究［J］. 中国现代医学杂志, 2014, 24(19): 96-99.

［5］ Su, X. , Wang, Y. , Zhou, G. et al. Probucol attenuates ethanol-induced liver fibrosis in rats by inhibiting oxidative stress, extracellular matrix protein accumulation and cytokine production［J］. Clinical and experimental pharmacology & physiology. , 2014, 41(1): 73-80.

［6］安文峰, 翟鲁辉, 马玉朝, 等. 丁苯酞对急性脑梗死患者血清炎症因子及氧化应激水平的影响［J］. 天津医药, 2017, 45(6): 610-613.

［7］卢丹丹, 王佩, 万莉, 等. 脑梗死患者尿酸、氧化应激水平与早期病情进展关系及普罗布考干预作用研究［J］. 临床军医杂志, 2017, 45(1): 56-59.

［8］ Dirleise Colle, Daniibia B. Santos, Juliana M. Hartwig et al. Succinobucol versus probucol: Higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro［J］. Mitochondrion, 2013, 13(2): 125-133.

［9］王福, 刘善文, 李彬, 等. rhEPO对氧化应激时心肌细胞及心肌梗死后心脏的保护作用［J］. 山东大学学报 (医学版), 2013, 51(7): 1-5, 9.

［10］王哲, 王秋实, 刘晓玉, 等. 糖基化终末产物调节氧化应激影响脐血间充质干细胞增殖及普罗布考保护作用［J］. 实用药物与临床, 2013, 16(4): 273-276.

［11］ Ishitobi, T. , Hyogo, H. , Tokumo, H. et al. Efficacy of probucol for the treatment of non-alcoholic steatohepatitis with dyslipidemia: An open-label pilot study［J］. Hepatology research: the official journal of the Japan Society of Hepatology, 2014, 44(4): 429-435.

［12］熊斌, 冯文伟, 林海云, 等. 急诊 PCI 应用前列地尔对急性 ST 段抬高型心肌梗死再灌注的影响［J］. 湖南师范大学学报 (医学版), 2015, (3): 79-80, 81.

［13］李云攀, 刘美云, 赵雯娜, 等. 瑞舒伐他汀联合普罗布考对大鼠动脉粥样硬化炎症与氧化应激的干预效果［J］. 中国Ñ证心血管医学杂志, 2014, (3): 352-355.

［14］ Ribeiro, R. P. , Moreira, E. L. G. , Santos, D. B. et al. Probucol affords neuroprotection in a 6-OHDA mouse model of Parkinson's disease［J］. Neurochemical research, 2013, 38(3): 660-668.

［15］胡艳, 王利民, 肖戈恵, 等. 超声心动图联合心电图QRS碎裂波诊断心肌梗死的效果分析［J］. 湖南师范大学学报 (医学版), 2017, 14(4): 53-55.

［16］ Fu Huaying, Li, Guangping, Liu, Changle et al. Probucol Prevents Atrial Remodeling by Inhibiting Oxidative Stress and TNF-alpha/NF-kappa B/TGF-beta Signal Transduction Pathway in Alloxan-Induced Diabetic Rabbits［J］. Journal of cardiovascular electrophysiology, 2015, 26(Pt.2): 211-222.