目的：探讨经皮腔内血管成形术（PTA）联合血管内支架对下肢动脉粥样硬化闭塞症（ASO）疗效及血管内皮功能和炎症因子的影响。方法：以2013年3月~2016年6月于我院受治的102例下肢ASO患者为研究对象。根据治疗方法分为对照组50例和观察组52例。对照组常规保守治疗，观察组在对照组基础上行PTA联合血管内支架治疗。比较两组治疗3个月后的临床疗效，治疗前和治疗1周后的血管内皮功能和炎症因子水平。结果：观察组的治疗总有效率78.85%，高于对照组64.00%；治疗前，两组的血管内皮素-1（ET-1）、一氧化氮（NO）和一氧化氮合酶（NOS）水平差异无统计学意义，两组治疗后的ET-1水平略低于且NO和NOS水平略高于治疗前，观察组治疗后的ET-1、NO和NOS水平变化幅度略小于对照组；两组治疗前的β2-微球蛋白（β2-M）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和超敏C反应蛋白水平差异无统计学意义，两组治疗后的β₂-M、TNF-α、IL-6和hsCRP水平低于治疗前，观察组治疗后的β₂-M、TNF-α、IL-6和hsCRP水平低于对照组。结论：PTA联合血管内支架治疗下肢ASO近期疗效明显，可降低患者体内β₂-M等炎症因子，对血管内皮功能影响小。

Objective To investigate the effect of percutaneous transluminal angioplasty (PTA) combined with endovascular stent for lower extremity arteriosclerosis obliterans (ASO) curative effect and vascular endothelial function and inflammatory factors. Methods From March 2013 to June 2016, 102 cases of patients with ASO were treated in our hospital, considered as the research object. According to the treatment methods, 102 cases of patients were divided into the control group (n=50) and the observation group (n=52). The control group conventional treatment, the observation group in the control group based on the PTA stent in the treatment of combined endovascular. Clinical efficacy and vascular endothelial function and inflammatory factor level of two groups were compared. Results Observation group total the efficiency was 78.85% and higher than control group . Before treatment, two groups of endothelin-1(ET-1), nitric oxide (NO) and nitric oxide synthase (NOS) were not statistically significant difference. After treatment, the two groups of ET-1 and NO and NOS level were slightly lower than before treatment. After treatment, the margin changes of ET-1, NO and the level of NOS in observation group were slightly less than the control group. The two groups before treatment of β2- microglobulin (β2-M), tumor necrosis factor α (TNF-α), interleukin-6(IL-6) and high sensitivity C reactive protein levels were no significant difference. After treatment, the β2-M. IL-6 and TNF-α, hsCRP level in two groups were lower than before treatment, and the observation group of β2-M, TNF-α, IL-6 and hsCRP levels were lower than the control group. Conclusion PTA combined with endovascular stent in the treatment of lower extremity ASO has obvious curative effect, can reduce the patients with β2-M and other inflammatory factors, and little effect on blood vessels endothelial function.