目的：探讨11 例席汉综合征患者的临床特征。 方法：收集2002 年1 月～201 年11 月在中南大学湘
雅二医院内分泌科确诊为席汉综合征的11 例住院患者的临床资料。结果：11 例席汉综合征患者中，确诊平均
年限为（1 .1±11.0）年。确诊席汉综合征患者再孕12 例（10%），其中长期接受激素替代 例（5%），再孕后病情缓解
1 例（0. %）。并发垂体危象 例（5 %），以垂体危象为首发症状者 例（ 5%），无垂体危象55 例（ %）。促性腺
激素减退症为101 例（ %），促甲状腺激素减退症占10 例（ %），促肾上腺皮质激素减退症占51 例（100%）。尿崩
症 例（ %）。 例行垂体MRI，其中，空泡蝶鞍2 例（55%），垂体萎缩1 例（ %）。 0 例行骨密度检查，骨质疏
松10 例（25%），低骨量2 例（5 %）。 结论：席汉综合征的病情轻重不一，临床表现存在多样性，早期正确诊断至关
重要。一方面诊断后及时靶腺激素替代治疗可避免垂体危象、骨质疏松症等的发生，另一方面病情轻者有可能再
孕，再孕后病情可改善或缓解。
Abstract
Objective To determine the clinical characteristics of 119 patients with Sheehan`s Syndrome (SS). Methods
We collected the clinical data of 119 inpatients diagnosed of SS in Department of Endocrinology, the Second Xiangya Hospital
, Central South University from January 2002 to November 2014. Results The mean period of diagnostic delay was（ 15.1±
11）years in these 119 patients with SS. 12 (10%) patients were pregnant again after being diagnosed with SS, 6（5%）of which
have long-term hormone replacement therapy, 1（0.8%） of which were pregnant again Get better. 64 (54%) developed pituitary
crisis and 55 (46%) did not, 48（75%）were pituitary crisis as first symptoms. 34（28.5%）had panhypopituitarism, while 85
（71.5%）had partial hypopituitarism. 101（97%）of the patients had gonadotropin deficiency, while 103（89%）of the patients had
TSH deficiency, and 51（100%）of the patients had ACTH deficiency. diabetes insipidus were 3 case（3%）. In 49 subjects having
magnetic resonance imaging of pituitary, 27 (55%) showed empty sella and 19 (39%) showed pituitary involution. Moreover, 40
subjects had bone mineral density examination, 10 (25%) of which showed osteoporosis and 23 (58%) of which showed osteopenia.
Conclusion Sheehan’s syndrome of severe situation is different, clinical manifestations are diverse, early correct diagnosis
is crucial. on the one hand, Prompt diagnosis and timely target gland hormone treatment can avoid pituitary crisis, osteoporosis,
etc, on the other hand, Sheehan’s syndrome of slight cases may be pregnant again, pregnant again after the SS can be improved
or alleviated.
关键词
席汉综合征 /
临床特征 /
腺垂体功能减退
Key words
Sheehan`s Syndrome /
Clinical characteristics /
Adenohypophysis hypofunction;
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