目的：探讨阿司匹林对脑梗死患者血同型半胱氨酸(Hcy) 的影响。方法：2012 年1 月～201 年12 月于本院神经内科住院的脑梗死患者100 例，随机分成非阿司匹林组50 例，阿司匹林组50 例。检测治疗前后患者血 Hcy、hs-CRP 水平，并采用美国国立卫生院神经功能缺损评分(NIHSS) 对患者治疗前后生活质量评估。结果：治疗后患者的血Hcy 、hs-CRP 水平明显降低，NISSH 评分明显降低，血Hcy、hs-CRP 水平与患者的NISSH 评分呈正相关。治疗后阿司匹林组Hcy 、hs-CRP 水平较非阿司匹林组明显降低。治疗后阿司匹林组NISSH 评分较非阿司匹林组降低，但无统计学意义。结论：阿司匹林治疗后脑梗死患者血清同型半胱氨酸(Hcy)、hs-CRP 水平降低，生活质量改善。
Abstract
Objective To investigate the effect of aspirin on bloodhomocysteine in patients with cerebral infarction.Methods One hundred patients between January 2012 and December 2013 wererandomly divided into non-aspirin group(50 cases), aspirin patients(50 cases). The levels of serum Hcy and hs-CRP were measured before and after treatment. The level of NIHSS were compared between pre- and post-treatment. Results After treatment, thelevels of serum Hcy and hs-CRP were significantly lower, NISSH score decreased significantly. NISSH score was positively related to the levels of serum Hcy, hs-CRP. After treatment, thelevels of serum Hcy and hs-CRP in aspirin-group weresignificantly lower than in non-aspirin group. After treatment, NISSH scoresin aspirin-group were lower than in non-aspirin group, but without statistical significance. Conclusion After treatment with aspirin, thelevels of Hcyand hs-CRP in patients withcerebral infarction were reduced, the quality of life improved.
关键词
阿司匹林 /
同型半胱氨酸 /
高敏C 反应蛋白 /
脑梗死
Key words
Aspirin /
homocysteine /
hs-CRP /
cerebral infarction
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参考文献
［1］ 樊东升.预防脑卒中要重视对高同型半胱氨酸水平的控制［J］.中华
老年医学杂志,2005, 2 ( ): 0 .
［2］ Kittner SJ,Giles WH,Macko RF,et al. Homocysteine andrisk of cerebral
infarction in a biracial population: the strokeprevention in young woman
study［J］.Stroke,1 , 0( ):155 -15 0.
［ ］ 梁容仙,廖仁昊,胡伟东.急性脑梗死患者氧化低密度脂蛋白、高敏
C-反应蛋白含量变化的研究［J］.现代预防医学,200 , 5( ): 5 - 5 .
［ ］ 赵凯.急性脑梗死患者血浆同型半胱氨酸和D-二聚体水平变化的
研究［J］.国际检验医学杂志,2011; 2( ):100 -100 .
［5］ Homocysteine Studies Collaboration. Homocysteine and risk of
ischemic heart disease andstroke: a meta-analysis［J］. JAMA,
2002;2 (1 ):2015-2022.
［ ］ 王鸿雁, 潘旭东, 韩仲岩. 同型半胱氨酸与脑血管病的临床研究［J］.
临床神经病学杂志, 2002, 15( ): 5 - 0.
［ ］ Boushey CJ, Beresford SA, Omenn GS, et al. A quantitative assessmentof
plasma homocysteine as a risk for vascular disease［J］. JAMA,1 5,
2 (1 ): 10 -105 .
［ ］ 李红伟, 李焰生. 同型半胱氨酸与神经系统疾病的研究进
展.200 ,1 ( ): - 5.
［ ］ 李志勇，李勋.C 反应蛋白与冠状动脉粥样硬化性心脏病［J］.医学
综述,200 , 1 ( 2 ): 5 0- 5 5．
［10］ 陈健, 张金枝.高同型半胱氨酸血症: 心脑血管疾病的独立危险因
子［J］. 心血管病学进展,2000,21(2): 5- .
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