目的：本研究旨在观察机动车尾气对大鼠气道高反应性的影响。方法：取 0 只SD 大鼠，随机分5 组：
正常对照组；吸入尾气2 天组；吸入尾气 天组；吸入尾气 天组；吸入尾气 天组，每组 只。采用小动物呼吸
机，肺组织切片PAS 和HE 染色，检测各组大鼠呼吸道反应性，肺组织杯状细胞化生指数、上皮粘液储备指数和炎
症细胞数量。结果：随着尾气吸入时间的延长，大鼠出现越来越明显的气道高反应性，同时，呼吸道粘液分泌量显
著增加，气道炎症明显加重。结论：吸入机动车尾气能引发并加重气道高反应性。
Abstract
Objective This study was designed to observe the impacts of the motor vehicle exhausts to airway hyperresponsiveness
in rats. Methods 30 Wister rats were randomly divided into 5 groups: normal control group; exhausts inhalation group
for two days, four days, six days and eight days, 6 rats in each group on average. Rodent ventilator and the technology of HE and
PAS stainings were used to observe the airway responsiveness in the lungs, the metaplasia of goblet cells index, the epithelial
mucous reserve index, the amount of inflammatory cells. Results With the time of exhausts inhalation extension, the airway hyperresponsiveness
is becoming more evident, while the amount of secretions of the airway mucus is increased rapidly; the airway
inflammation is become serious evidently. Conclusion The results given above reveal that the airway hyperresponsiveness could
be incurred and exacerbated through inhaling the motor vehicle exhausts.
关键词
机动车尾气 /
气道高反应性
Key words
motor vehicle exhausts /
airway hyperresponsiveness.
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