继发性肺结核患者血浆S100钙结合蛋白A9及凝血四项水平变化的临床意义分析

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Abstract Objective To investigate the clinical significance of the changes of plasma S100 calcium binding protein A9(S100A9) and four coagulation parameters in patients with secondary pulmonary tuberculosis. Methods A total of 217 patients with secondary pulmonary tuberculosis diagnosed in Guang'an People's Hospital from March 2021 to March 2023 were selected, and they were given 6 months of anti-tuberculosis treatment. Plasma S100A9 and four coagulation parameters [fibrinogen (FIB), thrombin time (TT), activated partial thromboplastin time (APTT) and prothrombin time (PT) ] were compared before and after treatment. After 6 months of standard treatment, patients in the observation group were divided into negative conversion group and non-negative conversion group based on treatment outcomes. Clinical data, S100A9 level and four coagulation parameters were compared between the two groups. The influencing factors of treatment outcome were analyzed. The diagnostic value of S100A9, PT, APTT, TT, and FIB in secondary pulmonary tuberculosis was analyzed using the area under the receiver operating characteristic (ROC) curve (AUC). Results S100A9, PT, APTT and FIB level were significantly higher and longer before treatment than after treatment. TT was significantly shorter before treatment than after treatment. After 6 months of standard treatment, the results of sputum smear testing for mycobacterium tuberculosis showed that there were 196 patients with negative conversion and 21 patients without. There were statistically significant differences in age, S100A9, PT, APTT and TT between the two groups. Binary logistic regression analysis found that age >60 years, high S100A9 level, long PT, long APTT and high FIB level were independent risk factors for treatment outcomes of secondary pulmonary tuberculosis, while long TT was a protective factor. The AUC values of S100A9, PT, APTT, TT, and FIB were 0.838, 0.710, 0.833, 0.841, and 0.649, respectively. Conclusion There are significant changes of S100A9 and four coagulation parameters in patients with secondary pulmonary tuberculosis. These parameters are closely related to the outcome of anti-tuberculosis treatment, and can serve as laboratory indicators for auxiliary diagnosis of secondary pulmonary tuberculosis.

Key words： secondary pulmonary tuberculosis plasma s100 calcium binding protein fibrinogen thrombin time prothrombin time activated partial thromboplastin time

Received: 03 January 2024

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R521

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	CHEN Zhifu
	DENG Jihong
	LI Lijuan

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CHEN Zhifu,DENG Jihong,LI Lijuan. Clinical Significance of the Changes of Plasma S100 Calcium Binding Protein A9 and Four Coagulation Parameters in Patients with Secondary Pulmonary Tuberculosis[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 73-77.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I3/73

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