多组分运动训练对老年肺结核衰弱患者炎症因子及氧化应激的影响

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Abstract Objective The aim of this study was to evaluate the effect of multicomponent exercise program on inflammatory factors and oxidative stress in frail elderly patients with pulmonary tuberculosis. Methods 66 frail elderly patients with pulmonary tuberculosis in Chest Center of Changsha hospital from April to October 2021 were selected by use of convenience sampling method, they were randomly divided into the intervention group (n=34) and the control group (n=32). In the control group, the routine care including tuberculosis care, nutritional guidance and exercise guidance was provided. In the intervention group, 12 weeks of multicomponent exercise in addition to routine care was provided. This study collected the baseline characteristics and compared the blood inflammatory biomarkers including interleukins 6(IL-6) and tumor necrosis factor-α (TNF- α) and C-reactive protein (CRP) and the superoxide dismutase (SOD) levels, frailty state Results After the intervention, the BMI of the intervention group was higher than that before and the control group, the weakness score was lower than that before and the control group, and the expression levels of serum IL-6, TNF-α, CRP and SOD were lower than that before and the control group. Conclusion Multicomponent exercise can effectively improve the elderly pulmonary tuberculosis patients’ frailty state, reduce expression of proinflammatory cytokines and superoxide dismutase levels.

Key words： tuberculosis frailty multicomponent exercise inflammation oxidative stress

Received: 24 January 2024

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R52

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	TAN Chuang
	WU Chuanfang
	SHU Ling
	LU Zhi
	ZHAO Hong
	Rao Qin
	Duan Lei

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TAN Chuang,WU Chuanfang,SHU Ling等. Effects of multicomponent exercise program on inflammatory factors and oxidative stress in frail elderly patients with pulmonary tuberculosis[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 91-95.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I3/91

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