Objective To observe the clinical effect of BIPAP of noninvasive ventilation in the treatment of COPD with left ventricular failure and pulmonary edema on the basis of conventional diuresis, cardiac and central excitatory drugs such as furosemide, digitalis and canola. Methods The clinical data of 135 patients with COPD complicated with left heart failure pulmonary edema from January 1, 2014 to December 31, 2016 in our hospital were retrospectively analyzed, and the patients were divided into observation group (n=68) and control group (n=67) according to different treatment methods. Among them, the control group was treated with furosemide, digitalis, canola and other conventional diuresis, cardiac and central excitatory drugs for treatment, while the observation group added BiPAP treatment based on the control. The general clinical indicators at 2 hours after the treatment, the treatment effect, cardiac function improvement and of lung function improvement at 3 months after the treatment of the two groups were compared. Results Two hours after the treatment, the levels of SBP, SDP, HR, PaO₂, PaCO₂, SaO₂ and Brog dyspnea score in the observation group were significantly better than those in the control group. Three months after the treatment, the total effective rate was 92.65% in the observation group, which was significantly higher than 79.10% in the control group; the cardiac parametersof LVEF, 6 min walking distance and BNP level in the observation group were significantly better than those in the control group, the lung function indexes of FEV₁, FEV₁/FVC and FEV₁% Pred in the observation group were significantly better than those in the control group. Conclusion For patients with COPD complicated with left heart failure and pulmonary edema, BiPAP treatment combined with conventional diuresis, cardiac and central excitatory drugs such as furosemide, digitalis and canola can significantly rapidlyrelieve the clinical symptoms of patients, improve the patient’s heart and lung function, and the treatment effect is better.