Abstract:Objective To explore the application of ultrasound-guided transversal abdominis plane block (TAPB) combined with rectus sheath block (RSB) during gynecological laparoscopic surgery. Methods 80 patients with gynecological laparoscopic surgery who received treatment in Anqing First People’s Hospital of Anhui Medical University from March 2021 to March 2023 were included and randomly divided into single group and combined group with 40 cases in each group. The single group received total intravenous anesthesia, and the combined group was given total intravenous anesthesia + TAPB combined with RSB anesthesia. Surgical indicators were compared between the two groups, and the hemodynamics [heart rate (HR), mean arterial pressure (MAP), oxygen saturation (SpO2) ] before anesthesia (T0), immediately after skin resection (T1) and at the end of surgery (T2). stress response indicators [C-reactive protein (CRP), interleukin-6(IL-6), tumor necrosis factor-α (TNF-α) ] at T0 and at 12 hours after surgery and analgesic effect [Visual Analogue Scale (VAS) ] at 4, 8 and 12 hours after surgery were compared between the two groups of patients. Results The spontaneous breathing time, first ambulation time and first exhaust time in combined group were shorter than those in single group. HR at T0-T2 in both groups was increased first and then decreased, and HR at T1 in combined group was lower than that in single group, and MAP was decreased first and then increased, and MAP in combined group at T1 was higher than that in single group. The levels of CRP, IL-6 and TNF-α in the two groups at 12 hours after surgery were enhanced compared with those at T0, but the levels in combined group were lower than those in single group. VAS score in combined group was lower than that in single group at 4, 8 and 12 hours after surgery. Conclusion TAPB combined with RSB has a good analgesic effect during gynecological laparoscopic surgery, and can stabilize the hemodynamics and relieve the stress response and postoperative pain.