Analysis of relationship between ultrasound image characteristics and clinicopathology and TCM syndrome type distribution in patients with granulomatous mastitis in mass stage
MA Feifei1, REN Yajuan1, XU Fang1, MENG Tian2
1. Department of Ultrasound, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China; 2. Breast Department of Traditional Chinese Medicine, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China
Abstract：Objective To explore the relationship between ultrasound image characteristics and clinicopathological staging and TCM syndrome type distribution in patients with granulomatous mastitis (GLM) in mass stage. Methods 56 patients with GLM in mass stage in the hospital were retrospectively selected from August 2022 to August 2023 and included in mass stage group. In addition, 30 patients with GLM in non-mass stage (abscess stage, post-ulcer stage) during the same time period were selected and enrolled as non-mass stage group. All patients underwent Doppler ultrasonography and were confirmed by pathology. The differences in ultrasound image characteristics (lesion size, shape, boundary, echo, calcification, catheter dilatation, blood flow signal) between the two groups were compared, and the relationship between ultrasound image characteristics and GLM in mass stage was analyzed by multivariate regression model. According to TCM syndrome types and tongue pulse conditions, the patients were divided into four syndromes: liver depression and phlegm coagulation syndrome, liver-stomach stagnation heat syndrome, phlegm-blood stasis blocking syndrome and yang deficiency and phlegm coagulation syndrome. The differences in ultrasound image characteristics were compared among patients with GLM in mass stage of different syndrome types. Results The proportions of lesions <6 cm, clear boundary, uniform echo, no calcification, no catheter dilatation and blood flow signal grade 0-I in mass stage group were significantly higher than those in non-mass stage group. Multivariate regression analysis showed that no catheter dilatation and blood flow signal grade 0-I were independent risk factors for GLM in mass stage. There was a statistically significant difference in the blood flow signal of ultrasound image among patients with different syndrome types of GLM in mass stage. The number of cases with blood flow signal grade 0-I in yang deficiency and phlegm coagulation syndrome (6 cases, 75.00%) was the highest, and the liver-stomach stagnation syndrome (2 cases, 12.50%) was the lowest. Conclusion The ultrasound image characteristics of lesion size, boundary, echo, calcification, catheter dilatation and blood flow signal in patients with different stages of GLM are different. Ultrasound images show that no catheter dilatation and blood flow signal grade 0-I are more likely to belong to GLM in mass stage. There are some differences in ultrasound blood flow signals under different TCM syndrome types of GLM in mass stage. Ultrasound blood flow signal can be used to assist the diagnosis of TCM syndrome differentiation of GLM in mass stage.
马菲菲, 任亚娟, 徐芳, 孟畑. 肉芽肿性乳腺炎肿块期患者超声图像特征与临床病理及中医证型分布的关系分析[J]. 湖南师范大学学报(医学版), 2024, 21(4): 59-64.
MA Feifei, REN Yajuan, XU Fang, MENG Tian. Analysis of relationship between ultrasound image characteristics and clinicopathology and TCM syndrome type distribution in patients with granulomatous mastitis in mass stage. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(4): 59-64.
2024, Vol. 21 
