Effects of Zishen Huoxue Antai decoction on hormone levels and uterine artery abnormalities in patients with recurrent abortion of kidney deficiency and blood stasis type
ZHU Xuhua1, FU Dongmei2, HUANG Yuxiao3
1. Department of Gynecology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102; 2. Department of Gynecology, Beijing Daxing District Maternal And Child Health Hospital, Beijing 102600; 3. Department of Gynecology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091
Abstract：Objective To study the effects of Zishen Huoxue Antai decoction on hormone levels and uterine artery abnormalities in patients with recurrent abortion of kidney deficiency and blood stasis type. Methods A total of 80 patients with recurrent abortion of kidney deficiency and blood stasis type admitted to Beijing Daxing District Maternal and Child Health Hospital from March 2019 to March 2022 were randomly divided into the conventional group（40 cases）and the traditional Chinese medicine group（40 cases）by random number table method. The conventional group received routine fetal preservation treatment,and was treated with dydrogesterone,vitamin E capsules,and low molecular weight heparin;the traditional Chinese medicine group was treated with Zishen Huoxue Antai decoction on the basis of the conventional group. Both groups were treated for 45 d,and the patients were followed up until delivery. The clinical efficacy of the two groups after 45 d of treatment and the pregnancy outcome during follow-up were analyzed,and the traditional Chinese medical syndrome scores,serum level of hormone,coagulation function,uterine artery and endometrial abnormalities were compared between the two groups before and after 45 d of treatment. Results After 45 d of treatment,the total effective rate of the traditional Chinese medicine group（92.50%）was higher than that of the conventional group（72.50%）;During the follow-up period,the success rate of pregnancy in the traditional Chinese medicine group（82.50%）was higher than that in the conventional group（62.50%）. During the follow-up period,the pregnancy success rate in the traditional Chinese medicine group was higher than that in the conventional group. After 45 d of treatment compared with before treatment,The scores of nocturnal frequent urination,lumbar and knee tenderness,cold limbs,dark face,dizziness and tinnitus,serum levels of D-D,FIB,PAI-1,uterine artery and endometrial PI,RI,S/D decreased in both groups. The traditional Chinese medicine group was lower than the conventional group. Serum levels of E2,P and β-HCG in two groups increased,and those in the traditional Chinese medicine group were higher than those in the conventional group. The aPTT in two groups was longer,and those in the traditional Chinese medicine group were longer than those in the conventional group. Conclusion Zishen Huoxue Antai decoction combined with routine abortion treatment could improve the traditional Chinese medical syndrome of patients with recurrent abortion of kidney deficiency and blood stasis,regulate the level of hormone,improve the coagulation function of patients,promote uterine artery and endometrial blood perfusion,improve the pregnancy outcome of patients,and the curative effect was good.
2023, Vol. 20 
