Hif-1α/Vegf信号通路活化对基底节出血患者病情的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (2635 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship between the expression of hypoxia-inducible factor 1α (HIF-1α) /vascular endothelial growth factor (VEGF) and the condition and prognosis of basal ganglia hemorrhage. Methods A total of 106 patients with basal ganglia hemorrhage from January 2019 to January 2022 were selected as the research subjects. The concentrations of serum HIF-1α and VEGF were measured by sandwich enzyme-linked immunosorbent assay with double antibodies. The associations between serum HIF-1α and VEGF concentrations and early neurological deterioration and poor prognosis 3 months after injury were analyzed by multivariate logistic regression, and the predictive power of the variables was assessed by receiver operating characteristic curve. Results The serum HIF-1α and VEGF concentrations at admission were significantly positively correlated with the admission NIHSS score (r=0.6267, 0.8495, both P<0.001). With the increase of baseline hematoma size, the serum HIF-1α and VEGF concentrations were significantly increased after acute ICH (r=0.5352, 0.6418, both P<0.001). Serum HIF-1α concentration (OR=4.054, 95%CI: 1.368-12.009; P=0.012) and serum VEGF concentration (OR=1.821, 95%CI: 1.119-2.965; P=0.016) were independent of END after acute ICH predictor. Serum HIF-1α concentration (OR=4.721, 95%CI: 1.662-13.407; P=0.014) and serum VEGF concentration (OR=2.198, 95%CI: 1.204-4.013, P=0.010) were associated with worse prognosis after acute ICH independent predictors. Serum HIF-1α concentration predicted early neurological deterioration (AUC=0.746, 95%CI: 0.6572-0.8178, P<0.001) and 3-month prognosis (AUC=0.7744, 95%CI: 0.7072-0.8416; P<0.001) was better than the serum VEGF concentrations (AUC=0.6882, 95%CI: 0.6113-0.7650; P<0.001 and AUC=0.7025, 95%CI: 0.6270-0.7780; P<0.001). Conclusion Serum HIF-1α and VEGF concentrations are independently associated with END and poor prognosis 3 months after ICH. In addition, the prognostic value of serum HIF-1α concentration is better than that of serum VEGF.

Key words： hypoxia-inducible factor 1α vascular endothelial growth factor basal ganglia hemorrhage condition prognosis

Received: 27 October 2023

PACS:

R743.34

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHAO Min
	YANG Yuying
	GAO Xiaoxia
	LI Jiming

Cite this article:

ZHAO Min,YANG Yuying,GAO Xiaoxia等. Effect of Hif-1α/Vegf signal pathway activation on the condition of patients with basal ganglia hemorrhage[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(2): 45-50.

URL:

http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I2/45

[1] 陈燕, 张秋, 尤年兴, 等. 急性缺血性脑卒中静脉溶栓后神经功能恢复及脑出血转化发生的影响因素分析[J]. 中华危重病急救医学, 2020, 32(11) : 1340-1345.
[2] 郭永涛, 李明超, 安坤, 等. 脑白质疏松对幕上自发性脑出血预后及血肿扩大的影响[J]. 中华神经医学杂志, 2020, 19(8) : 780-786.
[3] 郑海军, 戴凯茜, 娄晓辉, 等. 缺氧诱导因子-1α/血管内皮生长因子通路表达与高血压脑出血破入脑室患者颅内压及预后的相关性[J]. 中华高血压杂志, 2022, 30(3) : 283-286.
[4] 晋明璐, 陶陶, 邹哲华, 等. 重组腺病毒缺氧诱导因子-1α体外靶向性转染大鼠缺氧脑微血管内皮细胞的研究[J]. 中华老年医学杂志, 2020, 39(5) : 587-590.
[5] YU W, JIN H, SUN W, et al.Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypoperfusion[J]. J Cereb Blood Flow Metab, 2021, 41(10) : 2656-2675.
[6] SHIM J W, MADSEN J R.VEGF signaling in neurological disorders[J]. Int J Mol Sci, 2018, 19(1) : 275.
[7] BERNSTEIN J E, SAVLA P, DONG F, et al.Inflammatory markers and severity of intracerebral hemorrhage[J]. Cureus, 2018, 13(1) : e12605.
[8] WANG C L, XU Y W, YAN X J, et al.Usability of serum annexin A7 as a biochemical marker of poor outcome and early neurological deterioration after acute primary intracerebral hemorrhage: A prospective cohort study[J]. Front Neurol, 2022, 13: 954631.
[9] RADU R A, TERECOASA E O, TIU C, et al.Clinical Characteristics and Outcomes of Patients with Intracerebral Hemorrhage-A Feasibility Study on Romanian Patients[J]. J Med Life, 2020, 13(2) : 125-131.
[10] 毕胜, 盛宝英, 韩凤, 等. 缺氧诱导因子1α参与大脑中动脉闭塞模型大鼠的脑损伤与脑保护[J]. 中国组织工程研究, 2021, 25(35) : 5644-5649.
[11] 何秀慧. 缺氧诱导因子1α与核因子κB在炎症缺氧环境中相互作用研究进展[J]. 国际生物制品学杂志, 2020, 12(1) : 41-45.
[12] SHEN Y, GU J, LIU Z, et al.Inhibition of HIF-1α reduced blood brain barrier damage by regulating MMP-2 and VEGF during acute cerebral ischemia[J]. Front Cell Neurosci, 2018, 12: 288.
[13] PARK H, CHOI S H, KONG M J, et al.Dysfunction of 67-kDa laminin receptor disrupts BBB integrity via impaired dystrophin/AQP4 complex and p38 MAPK/VEGF activation following status epilepticus[J]. Front Cell Neurosci, 2019, 13: 236.
[14] YANG X, ZHANG Y, GENG K, et al.Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1α/VEGF Signaling and Blood-Brain Barrier Integrity[J]. Cell Mol Neurobiol, 2021, 41(6) : 1203-1215.
[15] LI J, LI C, YUAN W, et al.Targeted temperature management suppresses hypoxia-inducible factor-1α and vascular endothelial growth factor expression in a pig model of cardiac arrest[J]. Neurocritical Care, 2021, 35(2) : 379-388.
[16] 岑丽霞, 靳敏, 袁汝康. 急性脑出血患者血清HIF-1α与VEGF、Hsp70动态表达情况研究[J]. 临床与病理杂志, 2016, 36(8) : 1177-1181.