甘草锌联合微生态制剂治疗婴幼儿病毒性腹泻的疗效及对血清TNF-α、IL-6、GAS水平的影响

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Abstract Objective To study the efficacy of licorzinc combined with microecological preparation in the treatment of viral diarrhea in infants and its influence on serum tumor necrosis factor-α (TNF-α), interleukin-6(IL-6) and gastrin (GAS) levels. Methods 119 children with viral diarrhea who were diagnosed and treated in the hospital from June 2021 to August 2022 were selected and divided into control group (n=59, treated with microecological preparation) and study group (n=60, treated with licorzinc on the basis of control group) according to the random number table method. The efficacy, clinical recovery status, serum zinc element level, inflammatory factors and gastrointestinal hormones were compared between the two groups. Results The total effective rate of treatment in study group was 91.67% (55/60), which was higher than 77.97% (46/59) in control group. After treatment, the abdominal pain disappearance time, vomiting stop time, fever abatement time, stool recovery time, feeding time, virus negative conversion time and hospital stay in study group were shorter than those in control group. After 7 days of treatment, the levels of serum TNF-α and IL-6 in both groups were lower than those before treatment, and the above levels were lower in study group than those in control group, and the blood zinc level in study group was higher than that before treatment and higher than that in control group. The levels of serum GAS and plasma motilin (MOT) in both groups after 7 days of treatment were lower than those before treatment, and the levels in study group were lower compared with those in control group. The plasma somatostatin (SS) level in the two groups was higher than that before treatment, but there was no significant difference between the groups. Conclusion Licorzinc combined with microecological preparation in the treatment of viral diarrhea in infants can enhance the efficacy, relieve the symptoms and signs of fever, vomiting and diarrhea and increase the level of serum zinc element, and it has a good regulatory effect on serum inflammatory factors and gastrointestinal hormones.

Key words： licorzinc microecological preparation viral diarrhea efficacy serum inflammatory factors gastrointestinal hormones

Received: 28 June 2023

PACS:

R725.7

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	WANG Mi
	YANG Li
	GUO Dan
	LI Qiyong

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WANG Mi,YANG Li,GUO Dan等. Efficacy of licorzinc combined with microecological preparation on viral diarrhea in infants and influence on serum levels of TNF-α, IL-6 and GAS[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(4): 51-54.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I4/51

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