无创呼吸机联合乙酰半胱氨酸治疗伴Ⅱ型呼吸衰竭COPD患者的价值分析

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Abstract Objective To explore the clinical value of non-invasive ventilator ventilation combined with acetylcysteine (NAC) solution aerosol inhalation on patients with type II respiratory failure (RF) complicated with chronic obstructive pulmonary disease (COPD). Methods 169 patients with COPD complicated with type II RF who were treated in the hospital from May 2020 to January 2022 were divided into the control group (84 cases) and the observation group (85 cases) according to the random number table method. The control group was given conventional treatment combined with non-invasive ventilation, while the observation group was treated with NAC solution for aerosol inhalation on the basis of the control group, and both groups were treated for 7 days. The clinical efficacy, as well as blood gas indicators, respiratory mechanics changes and pulmonary function before and after treatment were observed in the two groups. Results The total effective rate was 97.65% in the observation group, which was higher than 88.10% in the control group. After 7 days of treatment, the partial pressure of oxygen (PaO₂), PH value and oxygen saturation (SpO₂₎in the observation group were higher while the partial pressure of carbon dioxide (PaCO₂) was lower compared to the control group. The tidal volume (VT) and fractional inspiratory time (Ti/Ttot) were higher while the respiratory rate (RR) was lower in the observation group compared to the control group. The forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and maximum ventilation volume (MVV) in the observation group were higher than those in the control group. Conclusion Non-invasive ventilator ventilation combined with aerosol inhalation of NAC solution can enhance the clinical efficacy, and effectively improve the blood gas indicators, respiratory mechanics indicators and pulmonary function in patients with COPD and type II RF.

Key words： non-invasive ventilator acetylcysteine aerosol inhalation type II respiratory failure chronic obstructive pulmonary disease

Received: 14 April 2023

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R563.8

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	Articles by authors
	MA Chunmei
	DUAN Ling
	DU Jing
	LI Hongyong

Cite this article:

MA Chunmei,DUAN Ling,DU Jing等. Value of non-invasive ventilator combined with acetylcysteine in the treatment of patients with type II respiratory failure and COPD[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(3): 84-87.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I3/84

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