腰椎术后那曲肝素钙预防下肢深静脉血栓的临床研究

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Abstract Objective To explore the safety and efficacy of low molecular Naqu heparin calcium in the prevention of deep vein thrombosis after lumbar spine surgery. Methods 78 Patients with lumbar spine surgery were randomly divided into observation group and control group. The patients of control group used physical prophylaxis to prevent deep vein thrombosis. The observation group used low-molecular Naqu heparin calcium to prevent DVT based on physical prophylaxis 12 hours after surgery. The amount of bleeding during the operation, the amount of drainage in the incision after the operation, the incisional bleeding and the occurrence of deep hematoma were recorded. The parameters of thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-dimer (DD) were recorded before and 3 and 7 days after operation. Ultrasonography was performed to record the thrombosis of the lower extremities before and 7-10 after the operation. Results There was no significant difference in the amount of blood loss during operation and the amount of wound drainage after operation between the two groups (P>0.05). There was no significant difference in the results of thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-dimer (DD) between the two groups before operation (P>0.05). There was no significant difference in prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) between the two groups at 3 days and 7 days post-operation (P>0.05). There were significant differences in fibrinogen (FIB) and D-dimer (DD) between observation group and control group at 3 days and 7 days post-operation, the levels of fibrinogen (FIB) and D-dimer (DD) in the observation group were significantly lower than those in the control group (P<0.05). In control group a DVT with symptom and two intermuscular vein thrombosis of shank with no symptom were taken place, and there was no DVT occur in observation group. Conclusion Using low-molecular Naqu heparin calcium does not increase the risk of intraspinal bleeding after lumbar spine surgery. it can reduce fibrinogen (FIB) and D-dimer (DD) levels, thus playing a role in preventing deep vein thrombosis in both lower limbs after lumbar spine surgery.

Key words： deep venous thrombosis (DVT) low molecular molecule Naqu heparin calcium lumbar operation fibrinogen (FIB) D-dimer (DD)

Received: 23 April 2023

PACS:

R681.5

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	XIANG Zhong
	CHEN Zhiwu
	HU Guohuang

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XIANG Zhong,CHEN Zhiwu,HU Guohuang. Clinical study on the prevention of deep vein thrombosis by using Naquheparin calcium after lumbar spine surgery[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(3): 80-83.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I3/80

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