达格列净联合胺碘酮治疗2型糖尿病合并阵发性房颤的疗效及对左心房功能及左心耳容积的影响

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Abstract Objective To observe the efficacy of Dapagliflozin combined with amiodarone in the treatment of patients with type 2 diabetes mellitus (T2DM) complicated with paroxysmal atrial fibrillation (PAF) and its effect on left atrial function and left atrial appendage volume. Methods 94 patients with T2DM complicated with PAF admitted to the Department of Cardiology of the third Xingtai hospital from August 2020 to November 2021 were selected as the research objects. They were randomly divided into control group and observation group, 47 cases in each group. The patients in the control group were treated with amiodarone orally after the treatment of basic diseases, and the patients in the observation group were treated with Dapagliflozin orally on the basis of the treatment of the control group. Both groups were treated for 6 months. The frequency of PAF, duration and average heart rate were observed before treatment, 3 months after treatment and 6 months after treatment; Doppler ultrasound was used to examine the changes of left atrial anteroposterior diameter (LAD), left atrial end diastolic area (LAEDA), atrial volume (AV), left atrial ejection fraction (LAEF) and left atrial appendage end diastolic volume (LAAEDV). Results The results of repeated measurement of variance showed that there were significant differences between the observation group and the control group in PAF attack frequency, duration, mean heart rate, FPG, 2hPG, HbA1c, LAD, LAEDA, AV, LAEF and LAAEDV at groups and time points before treatment, 3 months after treatment and 6 months after treatment; Compared with the control group, the number of PAF episodes, PAF duration, mean heart rate, FPG, 2hPG, HbA1c, LAD, LAEDA, AV and LAAEDV decreased, and LAEF increased in the observation group after treatment; The clinical efficacy of the observation group was better than that of the control group, and there was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Dapagliflozin combined with amiodarone has a good clinical effect in the treatment of T2DM complicated with PAF. The mechanism may be related to the further improvement of glucose metabolism and the improvement of left atrial structure and function.

Key words： type 2 diabetes paroxysmal atrial fibrillation dapagliflozin amiodarone left atrial function left atrial appendage volume

Received: 13 June 2022

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	Articles by authors
	SUN Xudu
	DONG Mei
	ZHANG Shan

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SUN Xudu,DONG Mei,ZHANG Shan. Effect of dagglitazone combined with amiodarone in the treatment of type 2 diabetes mellitus complicated with paroxysmal atrial fibrillation and its effect on left atrial function and left atrial appendage volume[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(1): 72-75.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I1/72

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