体细胞重编程成为干细胞及功能细胞的研究进展

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摘要体细胞可重编程为干细胞或功能细胞,如支持细胞重编程为多能干细胞和生殖干细胞,在再生医学与生殖医学有重要的应用。过表达基因激活类似细胞再生的程序,对人类体细胞重编程为干细胞或其他细胞提供了新方法。体细胞重编程调控干细胞的干性维持与干细胞命运决定。在本综述中,我们讨论体细胞重编程为多种干细胞及功能细胞的研究进展及其在转化医学的应用前景。

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	贺彩梅
	廖卓尔
	何祖平

关键词 ：体细胞, 重编程, 干细胞, 转化应用

Abstract：Somatic cells could be reprogrammed into stem cells and functional cells. As an example, Sertoli cells can be reprogrammed into pluripotent stem cells and germline stem cells, and thus they have significant applications in both regenerative and reproductive medicine. Overexpression of specific genes initiates a regenerative process of cells, which provides novel approaches for reprogramming human somatic cells into stem cells and other cells. Somatic cells reprogramming controls the stemness maintenance of stem cells and fate determinations of these cells. In this review, we discuss the recent advances in reprogramming somatic cells into various kinds of stem cells and functional cells. We also address the applications in of stem cells and functional cells derived from somatic cells in translational medicine.

Key words： somatic cells reprogramming stem cells translational applications

收稿日期: 2024-03-25

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基金资助:国家自然科学基金面上项目“人类支持细胞重编程为精原干细胞及分化为有功能的精子细胞的分子机制研究”（32170862）; 湖南省研究生创新项目“过表达 DAZL 家族基因重编程人支持细胞为精原干细胞及其分化为有功能的精子细胞的分子机制研究”（CX20220520）; 作者简介：何祖平,博士生导师,“潇湘学者”特聘教授,湖湘高层次人才聚焦工程-杰出创新人才; 时任“模式动物与干细胞生物学”湖南省重点实验室主任、“生殖与转化医学”湖南省工程研究中心主任、国家杰出青年基金评审专家、长江学者评审专家、科技创新领军人才评审专家; 主持国家自然科学基金重点项目、国家重点研发计划课题、国家重大科学研究课题（2项）、国家自然科学基金面上项目（4项）以及多项省、厅重点项目; 长期从事生殖医学、细胞生物学与分子生物学研究,其研究成果发表在国际著名期刊,如Cell Death and Differentiation、Research、Molecular Therapy-Nucleic Acids、Cell Death and Disease等

通讯作者: 何祖平,E-mail：zupinghe@hunnu.edu.cn

作者简介: #为并列第一作者

引用本文:

贺彩梅, 廖卓尔, 何祖平. 体细胞重编程成为干细胞及功能细胞的研究进展[J]. 湖南师范大学学报(医学版), 2024, 21(3): 1-6. HE Caimei, LIAO Zhuo'er, HE Zuping. Research advances in reprogramming somatic cells into stem cells and functional cells. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 1-6.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I3/1

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