长沙市孕妇妊娠早期血清全氟化合物暴露水平及影响因素研究

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摘要目的探究长沙市孕妇妊娠早期血清全氟化合物浓度水平现状及其影响因素,为孕期保健和孕妇全氟化合物浓度研究提供依据。方法选取湖南省长沙市妇幼保健院2022年孕检的孕妇进行问卷调查和血样检测,收集人口学特征、生活方式及孕检信息等资料,对全氟化合物浓度进行描述性分析并运用多元线性回归分析全氟化合物浓度的影响因素。结果长沙市孕妇血清中共检出23种全氟化合物,其中10种全氟化合物的检出率达到100%,13种全氟化合物检出率超过90%。孕妇血清中的全氟化合物浓度之间呈现不同程度的相关性（r=0.11~0.93）。全氟化合物总浓度值的中位数为7.572 9 ng/mL,全氟辛烷磺酸盐和全氟辛酸的浓度中位值分别为2.369 6 ng/mL和1.773 8 ng/mL。多元线性回归结果显示吸烟、年龄和住所打扫频率是全氟化合物浓度升高的危险因素,饮酒和孕次是全氟化合物浓度升高的保护因素。结论长沙市孕妇体内全氟化合物暴露水平与国内其他内陆城市人群的全氟化合物暴露水平相近。全氟化合物浓度的正关联影响因素有吸烟、年龄、住所打扫频率;全氟化合物浓度的负关联影响因素有饮酒和孕次。

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	林乐诗
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	黎丽
	彭芳
	彭冬梅
	秦露露
	高晓

关键词 ：全氟化合物, 多元线性回归, 影响因素, 孕妇, 血清

Abstract：Objective To explore the level of per- and polyfluoroalkyl substances (PFAS) in Changsha’s early pregnant women and the influencing factors of per-and polyfluoroalkyl substances, providing the prenatal care and evidence of concentration of PFAS in pregnant women. Method From among pregnant women who underwent prenatal examinations at Changsha Maternal and Child Health Hospital in Hunan Province in 2022, we selected participants for a questionnaire survey and blood sample testing. We collected pregnancy-related information, performed a descriptive analysis of PFAS concentration, and conducted a multiple linear regression analysis to identify factors that affect PFAS concentration. Results 23 PFAS were detected in the serum of pregnant women in Changsha, among which 10 compounds had a detection rate of 100%, and 13 compounds had a detection rate exceeding 90%. The median concentration of total PSASs was 7.572 9 ng/mL. The median concentrations of perfluorooctane sulfonic acid (PFOS) and perfluoro-n-octanoic acid (PFOA) were 2.369 6 ng/mL and 1.773 8 ng/mL. The multiple linear regression results showed that smoking, age, residence cleaning frequency, drinking and gravidity were the influencing factors of PFAS concentration. Conclusion The concentration of PFAS of pregnant women in Changsha is similar to that of other inland cities. The positive correlation factors affecting the level of PFAS are smoking, age and residence cleaning frequency; the negative correlation factor is drinking and gravidity.

Key words： per-and polyfluoroalkyl substances multiple linear regression influencing factors pregnant women serum

收稿日期: 2023-11-01

中图分类号:

R17

基金资助:湖南省自然科学基金青年基金“儿童期BMI生长轨迹对心血管代谢风险的影响——基于现有出生队列的研究”（2021JJ40367）; 湖南省卫生健康委科研课题“基于BKMR模型的产前 PFAS 暴露对新生儿出生结局的影响研究”（202212055647）; 湖南师范大学医学院开放课题“基于贝叶斯核机器回归模型的产前PFAS暴露对新生儿出生结局的影响及潜在机制研究”（KF2021016）; 湖南师范大学附属长沙市妇幼保健院区域遗传性出生缺陷防控研究湖南省重点实验室开放课题“父母重金属暴露对体外受精-胚胎移植母婴结局的影响研究”（HPKL2023024）

通讯作者: 高晓,E-mail：18670321975@163.com

引用本文:

林乐诗, 李文娟, 滕胜, 杨奕, 黎丽, 彭芳, 彭冬梅, 秦露露, 高晓. 长沙市孕妇妊娠早期血清全氟化合物暴露水平及影响因素研究[J]. 湖南师范大学学报(医学版), 2024, 21(1): 135-143. LIN Leshi, LI Wenjuan, TENG Sheng, Yang Yi, LI Li, PENG Fang, PENG Dongmei, QIN Lullu, GAO Xiao. Serum Levels of Per- and polyfluoroalkyl Substances and Their Determinants in Early Pregnant Women in Changsha City. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(1): 135-143.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I1/135

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