Abstract：Objective To analyze the occurrence of depression in patients with acute ischemic stroke (AIS) after intravenous thrombolysis, and construct a prediction model. Methods A total of 243 patients with AIS who underwent intravenous thrombolysis in the Third Hospital of Mianyang from January 2020 to December 2021 were selected as the study subjects. According to the presence or absence of depression after intravenous thrombolysis, the patients were divided into depression group (n=78) and non-depression group (n=165). Baseline data of the two groups were compared. Logistic regression analysis was conducted to identify the influencing factors of depression after intravenous thrombolysis for AIS, and a prediction model was constructed. The predictive value of the model was evaluated using the receiver operating characteristic (ROC) curve. Results Univariate analysis showed that there were statistically significant differences between the two groups in terms of age, BMI, accompanying mode, recent occurrence of negative life events, NIHSS score at admission and complications after thrombolysis. Logistic regression analysis found that age ≥ 60 years old, BMI ≥ 28 kg/m2, accompanied by nursing workers, negative life events occurring recently, the NIHSS score higher than 5 at admission, hemorrhage and ischemia-reperfusion injury after thrombolysis were risk factors for depression in patients with AIS after intravenous thrombolysis. A prediction model was constructed based on above-mentioned factors, and internal verification by Bootstrap method showed that the prediction curve was in good agreement with the standard model curve. ROC curve analysis showed that the sensitivity and specificity of the indicator Prob were 86.00% and 70.50%. Conclusion Age, BMI, accompanying mode, presence or absence of negative life events recently, the NIHSS score at admission and complications after thrombolysis are influencing factors of depression in patients with AIS after intravenous thrombolysis. The prediction model constructed based on above factors provides certain reference for predicting depression in AIS after intravenous thrombolysis.
2023, Vol. 20 
