Correlation between glycine and the pathogenesis of polycystic ovary syndrome
MA Yu1, CHEN Wenxin2, WU Wei3, XU Boqun1,2
1. The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing 211112, China; 2. The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210032, China; 3. The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Abstract：Objective To investigate the association between glycine and the pathogenesis of PCOS. Methods Glycine levels were detected and correlation analysis was performed in 11 PCOS patients and 11 healthy women. Mouse models were constructed and divided into Ctrl group, Gly group, PCOS group, and PCOS+Gly group. Estrous cycle and ovarian morphology were observed. Sex hormone and lipid metabolism indicators were detected. RT qPCR was used to detect the mRNA levels of hormone synthase and sex hormone receptor in ovarian tissues. Results (1) Serum glycine levels in PCOS patients were decreased compared to the control group and the values of FAI, LH and LH/FSH levels in PCOS patients were increased, while SHBG were decreased. In the total sample population, glycine levels were positively correlated with SHBG and negatively correlated with FAI and LH/FSH ratio. Glycine reduced body weight and TC and LDL-C levels of PCOS mice. It also accelerated the recovery of estrus cycle, reduced the number of cystic follicles and hemorrhagic cysts, and downregulated the mRNA levels of CYP17A1, CYP19A1, FSHR, and LHR. Conclusion Serum glycine levels were positively correlated with SHBG, and negatively correlated with FAI and LH/FSH ratio. PCOS patients exhibited a decrease in glycine levels. Glycine improved the disorder of lipid metabolism in PCOS mice, restored normal estrus cycle, protected normal ovarian morphology and regulated sex hormone levels. Glycine may inhibit the occurrence and development of PCOS by regulating the expression of genes related to hormone synthesis.
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2024, Vol. 21 
