Metabolic Regulation on Myelination and Remyelination
LI Pingping, JIANG Xinyue, HU Xinyue, LI Yawen, SONG Yixuan, ZHANG Mingliang
Department of Histoembryology, Genetics, and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China
Abstract：In the central nervous system (CNS), oligodendrocyte precursor cells (OPCs) proliferate, migrate, and differentiate into oligodendrocytes (OLs), which subsequently form myelin structure that ensheathes the axons of neurons. Myelin enables fast saltatory impulse propagation, provides energy and nutrition for neurons, and facilitates the establishment and maintenance of cognition. Notably, the (re) generation of myelin requires substantial energy consumption. Glucose, the preferred energy resource for many biological processes, plays a vital role in (re) myelination. Thus, we review the recent progress in the regulation of glucose metabolism on myelination to extend our understanding of myelination and to provide insights into the potential strategy for treating diseases of demyelination and neurodegeneration.
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2024, Vol. 21 
