Bibliometric Analysis of Trace Elements and Immunity Based on CiteSpace and VOSviewer
TANG Leting1,2, DONG Liping3, ZHAO Mingyi1
1. The Third Xiangya Hospital, Central South University, Changsha 410013, China; 2. The Second Xiangya Hospital, Central South University, Changsha 410011, China; 3. Changsha Medical University, Changsha 410219, China
摘要目的: 基于文献计量学方法对微量元素与免疫进行可视化分析,探索微量元素营养免疫学的研究热点和发展趋势,为临床实践及下一步研究提供参考依据。方法: 检索2000年1月—2022年12月Web of Science（WOS）核心合集数据库收录的微量元素免疫研究相关文献,运用CiteSpace和VOSviewer进行可视化分析及知识图谱绘制。结果: 筛选后共纳入1392篇文献,总体发文量逐年增加,特别是在2019年以后爆发式增长。中国和中国科学院分别是该研究领域发文量最多的国家和机构,但影响力远低于欧美国家。不同区域的作者、研究机构之间合作关系薄弱。Biological Trace Element Research是该领域最活跃的期刊。研究领域被分为9个聚类：营养支持,新型冠状病毒感染,维生素,硒,炎症性肠炎,肝病,老年人,系统性炎症,发病机制。肠道菌群、抑制和人类健康是最新的研究热点。结论: 微量元素与免疫在营养学研究领域发展前景良好。当前研究热点集中在肠道微生物群对免疫调节的影响、微量元素在新型冠状病毒感染、系统性炎症和肿瘤免疫疗法的调控机制以及膳食营养影响人体健康方面。
Abstract：Objective This study aims to employ bibliometric methods for a visual analysis of the intersection between trace elements and immunity. It investigates the research hotspots and development trends in this field and offers a reference for clinical practice and future research. Methods We retrieved publications on micronutrient immunology from the Web of Science Core Collection for the period between January 2000 and December 2022. The bibliometric and visualization analysis was conducted using CiteSpace and VOSviewer. Results Through screening, we identified a total of 1392 relevant publications, with a consistent increase in the publication count over the years, particularly post-2019. China and the Chinese Academy of Sciences emerged as the most productive country and institution, respectively, in this research area. However, their influence was comparatively lower than that of Europe and the United States. Collaboration between authors and institutions from different regions was found to be weak. The journal Biological Trace Element Research exhibited significant activity in this field. Our analysis resulted in the classification of research areas into 9 clusters, including nutritional support, COVID-19, vitamins, selenium, inflammatory bowel disease, liver disease, the elderly, systemic inflammation, and pathogenesis. The research frontiers encompass gut microbiota, inhibition, and human health. Conclusion The results of our bibliometric analysis suggest promising prospects for the development of micronutrient immunology. Current research endeavors focus on the impact of gut microbiota on immune response, the role of trace elements in the immunotherapy of COVID-19, systemic inflammation, and cancer, as well as the influence of dietary nutrition on human health.
[1] Gombart A F, Pierre A, Maggini S.A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection[J]. Nutrients, 2020, 12(1): 236. [2] Wintergerst E S, Maggini S, Hornig D H.Contribution of selected vitamins and trace elements to immune function[J]. Ann Nutr Metab, 2007, 51(4): 301-323. [3] Calder P C.Foods to deliver immune-supporting nutrients[J]. Curr Opin Food Sci, 2022, 43: 136-145. [4] Calder P C, Carr A C, Gombart A F, et al.Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections[J]. Nutrients, 2020, 12(4): 1181. [5] 付健, 丁敬达. Citespace和VOSviewer软件的可视化原理比较[J]. 农业图书情报, 2019, 31(10): 31-37. [6] Liang Y D, Li Y, Zhao J, et al.Study of acupuncture for low back pain in recent 20 years: a bibliometric analysis via CiteSpace[J]. J Pain Res, 2017, 10: 951-964. [7] Chen D, Zhang G, Wang J, et al.Mapping Trends in Moyamoya Angiopathy Research: A 10-Year Bibliometric and Visualization-Based Analyses of the Web of Science Core Collection (WoSCC)[J]. Front Neurol, 2021, 12: 637310. [8] Maggini S, Wintergerst E S, Beveridge S, et al. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses [J]. Br J Nutr, 2007, 98 Suppl 1: S29-35. [9] Shankar A H, Prasad A S.Zinc and immune function: the biological basis of altered resistance to infection[J]. Am J Clin Nutr, 1998, 68(2 Suppl): 447s-463s. [10] Michaudel C, Sokol H.The Gut Microbiota at the Service of Immunometabolism[J]. Cell Metab, 2020, 32(4): 514-523. [11] Limketkai B N, Hamideh M, Shah R, et al.Dietary Patterns and Their Association With Symptoms Activity in Inflammatory Bowel Diseases[J]. Inflamm Bowel Dis, 2022, 28(11): 1627-1636. [12] Huang L J, Mao X T, Li Y Y, et al. Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease [J]. Immunity, 2021, 54(8): 1728-1744. e7. [13] Bermano G, Méplan C, Mercer D K, et al.Selenium and viral infection: are there lessons for COVID-19?[J]. Br J Nutr, 2021, 125(6): 618-627. [14] Kieliszek M, Lipinski B.Selenium supplementation in the prevention of coronavirus infections (COVID-19)[J]. Med Hypotheses, 2020, 143: 109878. [15] Heller R A, Sun Q, Hackler J, et al.Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker[J]. Redox Biol, 2021, 38: 101764. [16] Karam G, Agarwal A, Sadeghirad B, et al.Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis[J]. Bmj, 2023, 380: e072003. [17] Thielmann C M, Costa da Silva M, Muley T, et al. Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma[J]. Sci Rep, 2019, 9(1): 11326. [18] Lv M, Chen M, Zhang R, et al.Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy[J]. Cell Res, 2020, 30(11): 966-979. [19] Wang C, Guan Y, Lv M, et al. Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses [J]. Immunity, 2018, 48(4): 675-687. e7.
2023, Vol. 20 
