盐酸氨溴索联合纤支镜肺泡灌洗治疗老年重症肺炎疗效及对氧化应激状态、炎症反应和肺泡氧合功能的影响

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摘要 目的：探讨盐酸氨溴索联合纤支镜肺泡灌洗应用于老年重症肺炎（severe pneumonia,SP）的效果。方法：选取2020年9月―2022年12月在本院就诊的老年SP患者100例,随机分为对照组和治疗组,各50例,对照组予以盐酸氨溴索治疗,治疗组在对照组的基础上采用纤支镜肺泡灌洗治疗,另选取同期采用常规治疗的50例患者为常规组。比较三组患者治疗后临床疗效,治疗前后氧化应激反应、炎症反应和肺泡氧合功能,以及治疗期间不良反应情况。结果：治疗后,治疗组总有效率高于对照组与常规组;治疗后,治疗组氧化应激反应、炎症反应和肺泡氧合功能等指标优于对照组与常规组;治疗期间,三组不良反应情况无明显差异。结论：相比常规治疗与盐酸氨溴索单药治疗老年SP,盐酸氨溴索联合纤支镜肺泡灌洗治疗,能增强临床疗效,降低氧化应激反应和炎症反应,改善肺泡氧合功能,安全性好。

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	黄敬应
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	张远聪

关键词 ：老年, 重症肺炎, 盐酸氨溴索, 纤维支气管镜肺泡灌洗

Abstract：Objective To explore the curative effect of ambroxol hydrochloride combined with bronchoscopic alveolar lavage in elderly patients with severe pneumonia (SP). Methods A total of 100 elderly patients with SP treated in the hospital were enrolled and randomly divided into control group and treatment group between September 2020 and December 2022, 50 cases in each group. The control group was treated with ambroxol hydrochloride, while treatment group was additionally treated with bronchoscopic alveolar lavage. A total of 50 patients given routine treatment during the same period were enrolled as routine group. The clinical curative effect after treatment, oxidative stress response, inflammatory response and alveolar oxygenation function before and after treatment, and adverse reactions during treatment in the three groups were compared. Results After treatment, total response rate of treatment group was higher than that of control group and routine group. After treatment, the related indexes of oxidative stress response, inflammatory response and alveolar oxygenation function in treatment group were better than those in control group and routine group. During treatment, there was no significant difference in adverse reactions among the three groups (P>0.05). Conclusion Compared with routine treatment and ambroxol hydrochloride alone, ambroxol hydrochloride combined with bronchoscopic alveolar lavage can enhance clinical curative effect, reduce oxidative stress response and inflammatory response, and improve alveolar oxygenation function in elderly patients with SP, with good safety.

Key words： elderly severe pneumonia ambroxol hydrochloride bronchoscopic alveolar lavage

收稿日期: 2023-03-21

中图分类号:

R563.1

基金资助:广西壮族自治区卫生健康委员会自筹科研课题（Z20200797）

通讯作者: 黄敬应,E-mail：hjywdq707119@163.com

引用本文:

黄敬应, 陆超灵, 覃仕跃, 唐弟雄, 张远聪. 盐酸氨溴索联合纤支镜肺泡灌洗治疗老年重症肺炎疗效及对氧化应激状态、炎症反应和肺泡氧合功能的影响[J]. 湖南师范大学学报(医学版), 2023, 20(3): 58-60. HUANG Jingying, LU Chaoling, QIN Shiyue, TANG Dixiong, ZHANG Yuancong. Curative effect of ambroxol hydrochloride combined with bronchoscopic alveolar lavage and its influences on oxidative stress, inflammatory response and alveolar oxygenation function in elderly patients with severe pneumonia. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(3): 58-60.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2023/V20/I3/58

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