老年心脑血管疾病患者认知功能障碍与维生素D水平、营养状态的关系

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摘要 目的：探讨老年心脑血管疾病患者认知功能障碍与维生素D水平、营养状态的关系。方法：回顾性分析2021年1月―2022年6月本院收治的237例老年心脑血管疾病患者资料。采用简易精神状态量表（MMSE）评估所有患者认知功能,比较不同认知功能情况的患者基础及临床资料的差异,并分析老年心脑血管疾病患者认知功能障碍的发生与维生素D水平、营养状态的关系。结果：237例老年心脑血管疾病患者中,84例合并认知功能障碍;相关性分析显示,患者MMSE评分与其微型营养评量表（MNA）评分、维生素D水平均呈正相关;认知功能障碍者有吸烟饮酒史、合并糖尿病占比均高于认知功能正常者,MNA评分及1,25-二羟维生素D₃[1,25-（OH）₂D₃]、高密度脂蛋白（HDL-C）水平低于认知功能正常者,低密度脂蛋白（LDL-C）水平高于认知功能正常者;多因素logistic回归分析显示,有合并糖尿病、HDL-C≤1.00 mmol/L、LDL-C≥3.40 mmol/L、MAN评分<17分及1,25-（OH）₂D₃≤50 nmol/L均为老年心脑血管疾病患者合并认知功能障碍的独立影响因素。结论：老年心脑血管疾病患者维生素D水平及营养状态均与其认知功能密切相关,且维生素D水平偏低及营养状况较差均为患者合并认知功能障碍的独立风险因素。

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	韩婷
	翟蒙恩
	张亚敏

关键词 ：老年, 心脑血管疾病, 认知功能障碍, 维生素D, 营养状态

Abstract：Objective To explore the relationship between cognitive dysfunction and vitamin D, nutritional status in elderly patients with cardiovascular and cerebrovascular diseases. Methods A retrospective analysis was performed on the data of 237 elderly patients with cardiovascular and cerebrovascular diseases admitted to the hospital between January 2021 and June 2022. The cognitive function of all patients was evaluated by mini-mental state examination (MMSE). The differences in basic and clinical data among patients with different cognitive function were compared. The relationship between cognitive dysfunction and vitamin D, nutritional status was analyzed. Results In the 237 elderly patients with cardiovascular and cerebrovascular diseases, there were 84 cases with cognitive dysfunction. Correlation analysis showed that MMSE score was positively correlated with score of Mini-Nutrition Assessment (MNA) and level of vitamin D. The proportions of smoking-drinking history and diabetes mellitus in patients with cognitive dysfunction were higher than those with normal cognitive function, MNA score and levels of 1, 25-dihydroxyvitamin D₃[1, 25- (OH) ₂D₃] and high density lipoprotein cholesterol (HDL-C) were lower than those with normal cognitive function, and level of low density lipoprotein cholesterol (LDL-C) was higher than that with normal cognitive function. Multivariate Logistic regression analysis showed that diabetes mellitus, HDL-C ≤1.00 mmol/L, LDL-C ≥3.40 mmol/L, MAN score <17 points and 1, 25- (OH) ₂D₃≤50 nmol/L were independent influencing factors of cognitive dysfunction in elderly patients with cardiovascular and cerebrovascular diseases. Conclusion The level of vitamin D and nutritional status are closely related to cognitive function in elderly patients with cardiovascular and cerebrovascular diseases. Low level of vitamin D and poor nutritional status are independent risk factors of cognitive dysfunction.

Key words： elderly cardiovascular and cerebrovascular disease cCognitive dysfunction vitamin D nutritional status

收稿日期: 2023-01-28

中图分类号:

R743

基金资助:国家自然科学基金（82000373）

通讯作者: 张亚敏,E-mail：270277955@qq.com

引用本文:

韩婷, 翟蒙恩, 张亚敏. 老年心脑血管疾病患者认知功能障碍与维生素D水平、营养状态的关系[J]. journal1, 2023, 20(2): 113-116. HAN Ting, ZHAI Meng'en, ZHANG Yamin. Relationship between cognitive dysfunction and vitamin D, nutritional status in elderly patients with cardiovascular and cerebrovascular diseases. journal1, 2023, 20(2): 113-116.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2023/V20/I2/113

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