Abstract：Objective To investigate the expression of miR-552 in colorectal cancer tissues and its relationship with clinicopathological characteristics. Methods 147 patients with colorectal cancer who were examined in our hospital from January 2020 to December 2022 were selected as the study subjects. The levels of miR-552 in tumor tissues and adjacent normal tissues were compared. According to the expression of miR-552, the subjects were divided into high expression group (miR-552 expression level was 1.28 or higher) and low expression group (miR-552 expression level was lower than 1.28). The risk factors affecting miR-552 expression were analyzed, and the correlation between miR-552 and pathological characteristics was discussed. Results The level of miR-552 in tumor tissue of patients with colorectal cancer (9.86±1.22) was higher than that in adjacent normal tissues. The proportions of TNM stage III and IV, tumor diameter ≥5 cm, serosal layer infiltration and lymph node metastasis in the high expression group were higher than those in the low expression group. Logistic regression analysis showed that TNM stage III and IV, tumor diameter ≥ 5cm, serosal layer infiltration and lymph node metastasis were independent influencing factors of high miR-552 expression. TNM stage, tumor diameter, invasion depth and lymph node metastasis were positively correlated with miR-552 expression. Conclusion The expression level of miR-552 in colorectal cancer tissue is higher than that in adjacent tissues, and TNM stage, tumor diameter, serosal layer infiltration, and lymph node metastasis are influencing factors for miR-552 expression level, which is significantly correlated with miR-552 expression level. .
2023, Vol. 20 
