Early diagnosis and operational reserarch of tumor lysis syndrome after c-TACE operation for massive hepatocellular carcinoma
MA JingPing1, LI Jiaxiang2, QIU Fang3, TAN Yongcai2
1. ZhuZhou HuiJia Cancer Hospital, Hunan Zhuzhou 412000, China; 2. JinShaZhou Hospital Of Guangzhou University Of Chinese Medicine, Guangzhou 510000, China; 3. Guangdong College of pharmacy attached three Hospital, Guangzhou 510000, China
Abstract：Objective To investigate the clinical early diagnosis and operational reserarch of tumor lysis syndrome (TLS) after c-TACE operation on patients with primary massive hepatocellular carcinoma. Methods The clinical data of 11 patients with primary massive hepatocellular carcinoma c-TACE complicated by tumor lysis syndrome operation from August 2016 to May 2021 were collected for retrospective analysis. Results All the 11 patients developed TLS within 72h after operation, accompanied by hyperuricemia in 11 cases (100%), hyperkalemia in 9 cases (81.8%), hyperphosphatemia in 8 cases (72.7%), hypocalcaemia in 4 cases (36.3%), increased creatinine in 4 cases (36.3%), and elevated lactate dehydrogenase in 11 cases. The main clinical manifestations are nausea, vomiting, chest tightness, wheezing, reduced urine volume, edema, tetany, most patients after timely replenishing hydration, correcting electrolyte disorders, reducing uric acid, hemodialysis and other treatment, abnormal indicators are most restored to the normal range within 1 week; One case died without treatment; One case died of acute renal failure, abnormal coagulation function and intracranial hemorrhage. Conclusion Patients with massive hepatocellular carcinomar are prone to TLS in the early postoperative period of c-TACE, TLS is a highly fatal disease, and laboratory indicators such as blood electrolytes, uric acid, renal function and urine output should be closely monitored during treatment. If diagnosed in time and effective therapeutic measures are implemented, the incidence of TLS and mortality can be reduced.
马静萍, 李家祥, 邱芳, 谭永才. 巨块型肝细胞癌c-TACE术后并发肿瘤溶解综合征早期诊断及其策略研究[J]. 湖南师范大学学报(医学版), 2023, 20(3): 114-118.
MA JingPing, LI Jiaxiang, QIU Fang, TAN Yongcai. Early diagnosis and operational reserarch of tumor lysis syndrome after c-TACE operation for massive hepatocellular carcinoma. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(3): 114-118.
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2023, Vol. 20 
