牛奶摄入与儿童过敏性鼻炎发病相关性的meta分析

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摘要 目的: 探讨牛奶对过敏性鼻炎（AR）发病率的影响。方法: 在PubMed、Embase和 Cochrane Library数据库经过检索式检索,筛取2001-2019年牛奶与AR关系的英文文献,筛选文献并对最终文献进行质量评分和数据提取,应用Stata 12.0统计软件进行荟萃分析。结果: 最终共纳入 12个研究,165966例患者。摄入牛奶与AR有关（RR=1.05,95％ CI：1.01~1.09）,亚组结果显示亚洲儿童服用牛奶（RR=1.24,95% CI：1.04~1.44）与大于七岁的儿童（RR=1.25,95% CI：1.05~1.46）可以增加AR的发病率。Begg's（P=0.950）以及Egger's（P=0.782）说明相关研究未显示发表偏倚。结论: 摄入牛奶与AR发病率增加有关,但还需要进一步的研究进行证明。

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	洪兰
	杨珊伊
	眭维恕
	袁驰与
	袁华兵
	尹美龙
	胡裕章

关键词 ：牛奶, 儿童过敏性鼻炎, 发病率, meta分析

Abstract：Objective This study aims to investigate the effect of milk on the incidence of allergic rhinitis (AR). Methods English literature on the relationship between milk and AR from 2001 to 2019 was selected in PubMed, Embase and Cochrane Library. Literature was screened and quality score and data extraction were performed on the final literature. Stata 12.0 statistical software was used for meta-analysis. Results A total of 12 studies and 165, 966 patients were included. Milk intake was associated with AR (RR=1.05, 95% CI: 1.01-1.09), and subgroup results showed that milk intake increased the incidence of AR in Asian children (RR=1.24, 95% CI: 1.04-1.4 4) and in children older than seven years (RR=1.25, 95% CI: 1.05-1.46). Begg's (P=0.950) and Egger's (P=0.782) indicated that the relevant studies did not show publication bias. Conclusion The results of this study suggest that intake of milk is associated with an increased incidence of AR, but further studies are needed to confirm this.

Key words： milk children with allergic rhinitis incidence meta-analysis.

收稿日期: 2021-11-20

中图分类号:

R765.21

基金资助:国家级大学生研究性学习和创新性实验计划项目（202112652004）; 湖北省卫生健康委员会联合基金项目（WJ2019H169）; 国家级大学生研究性学习和创新性实验计划项目（202210542028）

通讯作者: 尹美龙,E-mail：987137250@qq.com;胡裕章,E-mail：1323686030@qq.com

引用本文:

洪兰, 杨珊伊, 眭维恕, 袁驰与, 袁华兵, 尹美龙, 胡裕章. 牛奶摄入与儿童过敏性鼻炎发病相关性的meta分析[J]. 湖南师范大学学报(医学版), 2023, 20(1): 92-96. HONG Lan, YANG Shanyi, SUI Weishu, YUAN Chiyu, YUAN Huabing, YIN Meilong, HU Yuzhang. Meta-analysis of the relationship between milk intake and the incidence of children with allergic rhinitis. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(1): 92-96.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2023/V20/I1/92

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