Abstract：Objective To determine the clinical characteristics of 119 patients with Sheehan`s Syndrome (SS). Methods
We collected the clinical data of 119 inpatients diagnosed of SS in Department of Endocrinology, the Second Xiangya Hospital
, Central South University from January 2002 to November 2014. Results The mean period of diagnostic delay was（ 15.1±
11）years in these 119 patients with SS. 12 (10%) patients were pregnant again after being diagnosed with SS, 6（5%）of which
have long-term hormone replacement therapy, 1（0.8%） of which were pregnant again Get better. 64 (54%) developed pituitary
crisis and 55 (46%) did not, 48（75%）were pituitary crisis as first symptoms. 34（28.5%）had panhypopituitarism, while 85
（71.5%）had partial hypopituitarism. 101（97%）of the patients had gonadotropin deficiency, while 103（89%）of the patients had
TSH deficiency, and 51（100%）of the patients had ACTH deficiency. diabetes insipidus were 3 case（3%）. In 49 subjects having
magnetic resonance imaging of pituitary, 27 (55%) showed empty sella and 19 (39%) showed pituitary involution. Moreover, 40
subjects had bone mineral density examination, 10 (25%) of which showed osteoporosis and 23 (58%) of which showed osteopenia.
Conclusion Sheehan’s syndrome of severe situation is different, clinical manifestations are diverse, early correct diagnosis
is crucial. on the one hand, Prompt diagnosis and timely target gland hormone treatment can avoid pituitary crisis, osteoporosis,
etc, on the other hand, Sheehan’s syndrome of slight cases may be pregnant again, pregnant again after the SS can be improved
or alleviated.
2015, Vol. 12 
