Abstract：Objective To investigate the expression of leucine-rich-alpha-2-glycoprotein 1(LRG1 ) in hepatocellular carcinoma
(HCC) Cell lines and tissue, and to explore its relationship with HCC progression. Methods qRT-PCR and Western
blot analysis were used to detect LRG1 mRNA and protein expression respectively in 6 hepatocellular carcinoma cell lines, 30
paired HCC and adjacent normal liver tissues. Results The levels of LRG1mRNA and protein expression hepatocellular carcinoma
cell lines mRNA, protein levels LRG1 significantly higher than normal liver cells L02, the of invasion and metastasis
of HCC cell lines positive correlation with LRG1 expression levels. The levels of LRG1 mRNA and protein expression in HCC
were significantly higher than those in adjacent liver tissues. Conclusion LRG1 overexpression has a significant correlation
with the progression of HCC, and it would designing new targeted drugs.
2015, Vol. 12 
