视网膜血管形态学特征与急性轻症脑卒中患者脑侧支循环和预后的相关性研究

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Abstract Objective To analyze the correlation between the morphological characteristics of retinal blood vessels and the collateral circulation function of the pia mater, and to explore a predictive model for collateral circulation function and prognosis in patients with acute ischemic stroke. Method 53 patients with acute ischemic stroke were included and evaluated for collateral circulation score using head and neck CTA examination. They were divided into good collateral group and bad collateral group; Using the 90 day modified Rankin score as a prognostic indicator. Analyze fundus color photographs and extract morphological parameters of retinal blood vessels, including the main and branch diameters of retinal arteries and veins in each quadrant, curvature, balance, vascular tree classification dimension, geometric dimensions of the optic cup and disc, etc. Analyze the correlation between parameters with significant inter group differences, collateral circulation score, and stroke prognosis score, and establish a regression model for further validation. Result Among the cases included in this study, the good prognosis rate of the good collateral group was significantly higher than that of the bad collateral group. Among the morphological parameters of retinal blood vessels, the central retinal artery equivalent [(43.29±5.02) vs (39.05±4.21), P=0.002] and average arterial diameter [(51.49±5.35) vs (49.07±4.29) , P=0.040)] showed significant differences between groups. There was no significant difference in the other parameters. The central retinal artery equivalent and average arterial diameter were significantly correlated with the pia mater collateral circulation score, with correlation coefficients of 0.418 (P=0.002) and 0.290 (P=0.035) , respectively. There was no significant correlation between other parameters. The logistic regression analysis of collateral circulation score showed that CRAE was correlated with collateral circulation score (OR=1.349, 95% CI 1.101-1.653, P=0.004) , and the area under the ROC curve predicted by CRAE was 0.747 (95% CI 0.615-0.879, P=0.002) ; The mean arterial diameter was not statistically significant in the regression analysis of collateral circulation score (OR=1.086, 95% CI 0.976~1.209, P=0.129) . All retinal vascular parameters were not statistically significant in the 90 day modified Rankin score logistic regression. Conclusion In mild stroke patients, the central retinal artery equivalent is significantly correlated with the pia mater collateral circulation function, which can reflect the state of cerebral collateral circulation function. The morphological parameters of retinal blood vessels tested in this study cannot predict the prognosis of ischemic stroke.

Key words： ischemic stroke pia mater collateral circulation retinal blood vessels

Received: 28 September 2023

PACS:

R743.3

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	Articles by authors
	YU Wenxiao
	ZHENG Gu
	JIN Wangsheng
	ZHANG Meng
	SHEN Meixiao
	WANG Yanjiang

Cite this article:

YU Wenxiao,ZHENG Gu,JIN Wangsheng等. The correlation between morphological characteristics of retinal blood vessels and cerebral collateral circulation and prognosis in patients with acute minor stroke[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(6): 113-121.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I6/113

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