老年患者术后谵妄与围术期炎症因子变化及相关因素的关系

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Abstract Objective To investigate the relationship between postoperative delirium and perioperative inflammatory factors in elderly patients. Methods 260 elderly patients undergoing elective surgery in our hospital from August 2023 to May 2024 were collected. They were randomly divided into general anesthesia group (group G) and regional anesthesia group (group L), 130 cases in each group. The incidence of postoperative delirium, serum interleukin-6(IL-6), tumor necrosis factor-α (TNF-α) and central nervous system specific protein (S100-β) were compared between the two groups; Logistic regression model was used to analyze the univariate and multivariate factors affecting postoperative delirium. Results The incidence of postoperative delirium in group G was 23.84%, which was higher than that in group L (17 cases, 13.08%), and the difference was statistically significant; Serum IL-6, TNF-α and S100-β 3d after operation in the two groups were significantly higher than those before operation; There was no significant difference in IL-6, TNF-α and S100-β 3d after operation between the two groups; The preoperative MMSE score of patients with postoperative delirium was lower than that of patients without delirium, ASA grade, operation time, postoperative VAS score, IL-6, TNF-α And S100-β, proportion of elderly people were higher or longer than those in patients without delirium after operation; Logistic univariate analysis results: ASA classification, preoperative MMSE score, operation time, postoperative IL-6, TNF-α, S100-β, Anesthesia method, advanced age was related to postoperative delirium; Logistic multivariate analysis results: anesthesia mode (general anesthesia), preoperative MMSE score, postoperative IL-6, TNF-α And S100-β It was a risk factor for postoperative delirium. Conclusion Postoperative delirium in elderly patients and anesthesia methods, preoperative MMSE score, postoperative serum IL-6, TNF-α And S100-β, advanced age was monitoring the above factors can provide reference for the prevention and treatment of postoperative delirium.

Key words： old age postoperative delirium interleukin-6 tumor necrosis factor-α soluble protein-100β relativity

Received: 04 July 2024

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	YAO Yizhen
	TANG Jun
	ZHENG Yuqi
	WANG Fang
	LI Yanyan

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YAO Yizhen,TANG Jun,ZHENG Yuqi等. The relationship between postoperative delirium in elderly patients and changes in perioperative inflammatory factors and related factors[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(5): 111-115.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I5/111

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