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| Analysis of bacterial distribution and drug resistance of 526 patients with diabetes mellitus complicated by urinary tract infection in a hospital of Hunan |
| CAI Xiuyi1, WANG Hongbo2, TAN Zhixia1,3, LIU Yuanqi1, LIU Jiaxin1, CAO Xiaomei1, ZHANG Biming4, YE Xiangli1,5 |
1. School of Medicine, Hunan Normal University, Changsha 410013, China;
2. Hunan Provincial People's Hospital/the First Affiliated Hospital, Changsha 410005, China;
3. The Ninth Hospital of Changsha, Changsha 410014, China;
4. The Fourth Hospital of Chagsha / the Affiliated Changsha Hospital of Hunan Normal University, Changsha 410006, China;
5. The Research Center of Reproduction and Translational Medicine of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, China |
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Abstract Objective To study the pathogenic bacteria distribution and drug resistance of urinary system infection in inpatients with diabetes, and to provide scientific basis for clinical screening of antibiotics to guide rational drug use. Methods 526 midcourse urine samples from inpatients with diabetes complicated with urinary system infection in a hospital of Hunan Province from January 2021 to May 2023 were selected, and then isolation culture and drug sensitivity experiments were carried out to observe and compare the distribution of pathogenic bacteria and drug resistance rates among patients of different genders and ages. Results A total of 609 strains of bacteria were isolated and cultured. The main strains of Gram-negative bacteria (G-) were Escherichia coli and Klebsiella pneumoniae, and the main strains of Gram-positive bacteria (G+) were Enterococcus faecium and Enterococcus faecalis. The resistance rate of Escherichia coli to levloxacin and ciprofloxacin was 77.83% and 66.02%, respectively, and it was highly sensitive to tigacycline and colistin. The resistance rate of Klebsiella pneumoniae to levofloxacin was the highest (60.27%). Among the main G+ bacteria, Enterococcus faecium had high resistance rates to penicillin, ampicillin, ciprofloxacin, levofloxacin and erythromycin (98.17%, 92.66%, 88.07%, 93.58%, 93.58%), and was sensitive to quinuptidine/dafoptidine, linezolid, vancomycin, tetracycline and tigacycline, respectively. Enterococcus faecalis had high resistance rates to erythromycin, tetracycline, quinuptine/Dafoptene (96.67%, 96.67%, 76.67%, respectively), and was highly sensitive to penicillin, ampicillin, ciprofloxacin, levofloxacin, vancomycin and tigacycline. Escherichia coli accounted for the highest proportion in different gender groups, and the isolation rate of Escherichia coli in female patients was significantly increased. In different age groups, with the increase of host age, the sensitivity of Escherichia coli to different antibiotics showed different trends. Conclusion The main pathogenic bacteria in patients with diabetes complicated with urinary system infection are gram-negative bacteria, and the resistance rate of these pathogenic bacteria to commonly used antibiotics is significantly different, and it changes with the difference of gender and age. This study provides a basis for the rational clinical use of drugs in Hunan Province, the prevention of the spread of drug-resistant bacteria, and the active exploration and research of new treatments to deal with the increasingly severe situation of bacterial resistance.
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Received: 30 November 2023
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CAI Xiuyi,WANG Hongbo,TAN Zhixia等. Analysis of bacterial distribution and drug resistance of 526 patients with diabetes mellitus complicated by urinary tract infection in a hospital of Hunan[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 141-145.
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| URL: |
| http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2024/V21/I3/141 |
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2024, Vol. 21 
