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| A meta-analysis of Krebs von den Lungen-6 to determine the severity of COVID-19 |
| YANG Jialu1, YOU Qian1, PENG Qian2, WU Yi1 |
1. Hunan Provincial People's Hospital /The First Hospital Affiliated to Hunan Normal University, Changsha 410005, China;
2. Schoo of Medicine, Hunan Normal University, Changsha 410013, China |
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Abstract Objective Krebs von den Lungen-6(KL-6) is a glycoprotein mainly secreted by type II alveolar epithelial cells. Blood levels of KL-6 appear to be correlated with the severity of COVID-19 patients. Therefore, we conducted a meta-analysis in this paper to assess the role of serum KL-6 levels in determining the severity of COVID-19 patients. Methods The relevant literatures from December 2019 to December 2022 were searched in PUBMED, the Cochrane Library, CNKI and Wanfang Medical database. A total of 9 studies were included and pooled in the meta-analysis. Use RevMan 5.4 and Stata 17.0 for summary, integration and analysis. Results Serum KL-6 in severe patients was significantly higher than that in mild patients in 9 studies (SMD=1.14, 95%CI: 0.79-1.49). The composite diagnostic parameters calculated in the four studies were sensitivity 0.63(95% CI: 0.51 - 0.75), specificity 0.88(95% CI: 0.84 - 0.91), positive likelihood ratio 5.23(95% CI: 3.99- 6.85), negative likelihood ratio 0.42(95% CI: 0.30 - 0.57), and area under the receiver operating characteristic curve 0.87. Conclusion KL-6 levels were significantly elevated in patients with a more advanced course of COVID-19, suggesting that KL-6 may be an effective test for identifying risk in patients with severe COVID-19.
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Received: 16 February 2023
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2023, Vol. 20 
