酒精相关性肝病致病机制与诊疗研究进展

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Abstract Alcohol associated liver disease (ALD) has become a major cause of cirrhosis and liver failure across the world and its influence continues to increase. ALD encompasses a spectrum of diseases including asymptomatic liver steatosis, alcohol-associated hepatitis, alcohol associated fibrosis, cirrhosis, and even liver cancer. The progression of ALD involves in multiple cell types and even different organs including liver and gut. More importantly, there are very limited options for treatment of ALD currently due to the lack of effective diagnosis methods and clinical symptoms which resultes in patients with ALD are rarely diagnosed in the earlier phase of the disease spectrum. Therefore, it is of great strategic significance to deeply study the pathogenesis of ALD and clinical application value to develop effective diagnosis and treatment strategies. In present review, we discussed recent advances on the pathogenesis, current treatment options, and clinical trials of ALD.

Key words： alcohol associated liver disease pathogenesis early diagnosis treatment options

Received: 16 June 2023

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R575

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	LIANG Gaoshuang
	PENG Jinying
	LI Zhuan

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LIANG Gaoshuang,PENG Jinying,LI Zhuan. Advances on the study of pathogenesis and treatment of alcohol-associated liver disease[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(4): 1-10.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I4/1

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