Effects of multicomponent exercise program on inflammatory factors and oxidative stress in frail elderly patients with pulmonary tuberculosis
TAN Chuang1, WU Chuanfang2, SHU Ling3, LU Zhi1, ZHAO Hong1, Rao Qin1, Duan Lei4
1. Chest Center, 2. Department of nursing, 3. Department of Otorhinolaryngology Head and Neck Surgery, 4. Department of Rehabilitation Medicine, Changsha Central Hospital/ The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, China
Abstract：Objective The aim of this study was to evaluate the effect of multicomponent exercise program on inflammatory factors and oxidative stress in frail elderly patients with pulmonary tuberculosis. Methods 66 frail elderly patients with pulmonary tuberculosis in Chest Center of Changsha hospital from April to October 2021 were selected by use of convenience sampling method, they were randomly divided into the intervention group (n=34) and the control group (n=32). In the control group, the routine care including tuberculosis care, nutritional guidance and exercise guidance was provided. In the intervention group, 12 weeks of multicomponent exercise in addition to routine care was provided. This study collected the baseline characteristics and compared the blood inflammatory biomarkers including interleukins 6(IL-6) and tumor necrosis factor-α (TNF- α) and C-reactive protein (CRP) and the superoxide dismutase (SOD) levels, frailty state Results After the intervention, the BMI of the intervention group was higher than that before and the control group, the weakness score was lower than that before and the control group, and the expression levels of serum IL-6, TNF-α, CRP and SOD were lower than that before and the control group. Conclusion Multicomponent exercise can effectively improve the elderly pulmonary tuberculosis patients’ frailty state, reduce expression of proinflammatory cytokines and superoxide dismutase levels.
[1] DENT E, MORLEY JE, CRUZ-JENTOFT AJ, et al.Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management[J]. J Nutr Health Aging, 2019, 23(9): 771-787. [2] KHAN H, KALOGEROPOULOS A P, GEORGIOPOULOU V V, et al.Frailty and risk for heart failure in older adults: the health, aging, and body composition study[J]. Am Heart J, 2013, 166(5): 887-894. [3] FRIED L P, TANGEN C M, WALSTON J, et al.Frailty in older adults: evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-M157. [4] 曹春乐. 老年肺结核患者衰弱现状及影响因素研究[D]. 湖南: 湖南师范大学, 2021. [5] ANGULO J, EL ASSAR M, ÁLVAREZ-BUSTOS A, et al.Physical activity and exercise: Strategies to manage frailty[J]. Redox Biol, 2020, 35: 101513. [6] ÁLVAREZ-SATTA M, BERNA-ERRO A, CARRASCO-GARCIA E, et al.Relevance of oxidative stress and inflammation in frailty based on human studies and mouse models[J]. Aging (Albany NY).2020, 12(10): 9982-9999. [7] GARCÍA-ESQUINAS E, GUALLAR-CASTILLÓN P, CARNICERO J A, et al. Serum uric acid concentrations and risk of frailty in older adults[J]. Exp Gerontol, 2016, 82: 160-165. [8] CHEN Y, LIU S, LENG S X.Chronic Low-grade Inflammatory Phenotype (CLIP) and Senescent Immune Dysregulation[J]. Clin Ther, 2019, 41(3): 400-409. [9] SOYSAL P, STUBBS B, LUCATO P, et al.Corrigendum to" Inflammation and frailty in the elderly: A systematic review and meta-analysis"[J]. Ageing Res Rev, 2017, 35: 364. [10] DEEPA SS, BHASKARAN S, ESPINOZA S, et al.A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse[J]. Geroscience, 2017, 39(2): 187-198. [11] 曹亭, 刘启帆, 施月仙, 等. 运动联合营养支持对衰弱期及衰弱前期老年人影响的Meta分析[J]. 中国护理管理, 2019, 19(1): 52-59. [12] 谭春苗, 王小环, 王芳, 等. 多组分运动训练对老年慢性阻塞性肺疾病患者运动功能和呼吸功能的影响 [J]. 中国康复医学杂志, 2023, 38(11): 1566-1570+1575. [13] 梁倩, 汪晓丽, 刘梦琪, 等. 多组分运动护理干预在老年慢性心力衰竭合并衰弱患者中的应用[J]. 中华护理杂志, 2023, 58(23): 2821-2828. [14] ARRIETA H, REZOLA-PARDO C, GIL SM, et al.Effects of Multicomponent Exercise on Frailty in Long-Term Nursing Homes: A Randomized Controlled Trial[J]. J Am Geriatr Soc, 2019, 67(6): 1145-1151. [15] LOSA-REYNA J, BALTASAR-FERNANDEZ I, ALCAZAR J, et al.Effect of a short multicomponent exercise intervention focused on muscle power in frail and pre frail elderly: A pilot trial[J]. Exp Gerontol, 2019, 115: 114-121. [16] 李鑫, 赵蕊, 张慧鑫. 个体化多组分运动管理在老年衰弱患者中的应用效果[J]. 中国护理管理, 2022, 22(8): 1164-1169. [17] ABELLAN VAN KAN G, ROLLAND Y, BERGMAN H, et al. The I. A. N. A Task Force on frailty assessment of older people in clinical practice[J]. J Nutr Health Aging, 2008, 12(1): 29-37. [18] CADORE E L, CASAS-HERRERO A, ZAMBOM-FERRARESI F, et al.Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians[J]. Age, 2014, 36(2): 773-785. [19] 谭春苗, 姜芬, 王小环, 等. 多组分运动训练方案对老年COPD病人四肢骨骼肌功能的影响[J]. 护理研究, 2023, 37(22): 4106-4110. [20] POJEDNIC R M, CLARK D J, PATTEN C, et al.The specific contributions of force and velocity to muscle power in older adults[J]. Exp Gerontol, 2012, 47(8): 608-613. [21] SADJAPONG U, YODKEEREE S, SUNGKARAT S, et al.Multicomponent Exercise Program Reduces Frailty and Inflammatory Biomarkers and Improves Physical Performance in Community-Dwelling Older Adults: A Randomized Controlled Trial[J]. Int J Environ Res Public Health, 2020, 17(11): 3760. [22] ROSS M, LITHGOW H, HAYES L, et al.Potential Cellular and Biochemical Mechanisms of Exercise and Physical Activity on the Ageing Process[J]. Subcell Biochem, 2019, 91: 311-338. [23] RUSIP G, ILYAS S, LISTER INE, et aI. The effect of ingestion of red dragon fruit extract on levels of malondialdehyde and superoxide dismutase after strenuous exercise in rats (Rattus norvegicus)[J]. F1000Res, 2021, 10: 1061. [24] 谢永超. 有氧耐力运动结合间歇断食对大鼠组织抗氧化作用研究[D]. 郑州: 郑州大学, 2021. [25] 于影, 蔡奔, 吕恒, 等. 血清超氧化物歧化酶介导的发病前体育运动对缺血性脑卒中患者认知功能改善作用的队列研究[J]. 中华疾病控制杂志, 2021, 25(11): 1303-1308.
2024, Vol. 21 
