甘草锌联合微生态制剂治疗婴幼儿病毒性腹泻的疗效及对血清TNF-α、IL-6、GAS水平的影响

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摘要 目的: 研究甘草锌联合微生态制剂治疗婴幼儿病毒性腹泻的疗效及对血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、胃泌素（GAS）水平的影响。方法: 选取2021年6月—2022年8月期间我院诊治的119例病毒性腹泻患儿,依据随机数字表法分为对照组（n=59例,予以微生态制剂治疗）和研究组（n=60例,在对照组基础上联合甘草锌治疗）。对比两组疗效、临床恢复情况、血清锌元素水平、炎症因子以及胃肠激素水平。结果: 研究组治疗总有效率为91.67%（55/60）,高于对照组的77.97%（46/59）。治疗后,研究组腹痛消失时间、呕吐停止时间、退热时间、大便恢复时间、进食时间、病毒转阴时间以及住院时间均短于对照组。治疗7天后,两组血清TNF-α、IL-6水平均低于同组治疗前,且研究组低于对照组,研究组血锌水平高于同组治疗前及对照组。治疗7天后,两组血清GAS水平、血清胃动素（MOT）均低于同组治疗前,且研究组低于对照组,两组血清生长抑素（SS）水平均高于同组治疗前,但组间比较无明显差异。结论: 甘草锌联合微生态制剂用于治疗婴幼儿病毒性腹泻可提高疗效,缓解患儿发热、呕吐、腹泻等症状与体征,提高血清锌元素水平,且对血清炎症因子以及胃肠激素具有较好的调控效果,值得临床推广应用。

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关键词 ：甘草锌, 微生态制剂, 病毒性腹泻, 疗效, 炎症因子, 胃肠激素

Abstract：Objective To study the efficacy of licorzinc combined with microecological preparation in the treatment of viral diarrhea in infants and its influence on serum tumor necrosis factor-α (TNF-α), interleukin-6(IL-6) and gastrin (GAS) levels. Methods 119 children with viral diarrhea who were diagnosed and treated in the hospital from June 2021 to August 2022 were selected and divided into control group (n=59, treated with microecological preparation) and study group (n=60, treated with licorzinc on the basis of control group) according to the random number table method. The efficacy, clinical recovery status, serum zinc element level, inflammatory factors and gastrointestinal hormones were compared between the two groups. Results The total effective rate of treatment in study group was 91.67% (55/60), which was higher than 77.97% (46/59) in control group. After treatment, the abdominal pain disappearance time, vomiting stop time, fever abatement time, stool recovery time, feeding time, virus negative conversion time and hospital stay in study group were shorter than those in control group. After 7 days of treatment, the levels of serum TNF-α and IL-6 in both groups were lower than those before treatment, and the above levels were lower in study group than those in control group, and the blood zinc level in study group was higher than that before treatment and higher than that in control group. The levels of serum GAS and plasma motilin (MOT) in both groups after 7 days of treatment were lower than those before treatment, and the levels in study group were lower compared with those in control group. The plasma somatostatin (SS) level in the two groups was higher than that before treatment, but there was no significant difference between the groups. Conclusion Licorzinc combined with microecological preparation in the treatment of viral diarrhea in infants can enhance the efficacy, relieve the symptoms and signs of fever, vomiting and diarrhea and increase the level of serum zinc element, and it has a good regulatory effect on serum inflammatory factors and gastrointestinal hormones.

Key words： licorzinc microecological preparation viral diarrhea efficacy serum inflammatory factors gastrointestinal hormones

收稿日期: 2023-06-28

中图分类号:

R725.7

基金资助:2021年干部保健科研课题立项项目（2021-203）

通讯作者: 王觅,E-mail：Wangm10060@163.com

引用本文:

王觅, 杨莉, 郭丹, 李其勇. 甘草锌联合微生态制剂治疗婴幼儿病毒性腹泻的疗效及对血清TNF-α、IL-6、GAS水平的影响[J]. 湖南师范大学学报(医学版), 2023, 20(4): 51-54. WANG Mi, YANG Li, GUO Dan, LI Qiyong. Efficacy of licorzinc combined with microecological preparation on viral diarrhea in infants and influence on serum levels of TNF-α, IL-6 and GAS. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(4): 51-54.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2023/V20/I4/51

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