如意金黄散在阳证疮疡中的抗炎作用及对NLRP1/Caspase-1通路的影响

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摘要 目的: 探究如意金黄散对阳证疮疡炎症反应及红肿热痛证的改善作用,初步揭示如意金黄散对阳证疮疡中NLRP1/caspase-1通路的影响,以期为后续基础研究提供有力的临床依据。方法: 选取2021年2月―2023年1月间我院收治的105例阳证疮疡患者,根据治疗方式分为对照组（n=35）及观察组（n=70）,对照组接受夫西地酸外敷治疗,观察组接受如意金黄散外敷治疗。比较两组患者的临床疗效,比较两组患者治疗前及治疗21天后红肿范围、疼痛评分、白细胞水平、中性粒细胞百分比以及血清NLRP1、Caspase-1、IL-1β、IL-18水平。结果: 与治疗前相比,治疗21天后两组患者红肿范围缩小,疼痛评分、白细胞水平、中性粒细胞百分比、血清IL-1β、IL-18、NLRP1、Caspase-1均显著降低。治疗21天后观察组与对照组相比,临床疗效增加,红肿范围、疼痛评分、白细胞水平、中性粒细胞百分比、血清IL-1β、血清IL-18、NLRP1、Caspase-1均显著减小。结论: 如意金黄散有效改善了阳证疮疡患者的红肿热痛症状,显著抑制患者体内炎症反应及NLRP1/Caspase-1通路。本研究提示了如意金黄散基于NLRP1/Capase-1通路治疗阳证疮疡的潜在作用机制,为后续基础实验提供有力的前期依据。

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	郭维
	向丽萍
	宋晓玲

关键词 ：阳证疮疡, 如意金黄散, NLRP1, Caspase-1

Abstract：Objective This study aims to explore the role of Ruyi Gold en Powder on inflammation and redness and swelling, heat and pain syndrome in skin and external diseases with Yang yndrome (SKDYS), and preliminarily reveal the influence of Ruyi Golden Powde on NLRP1/caspase-1 pathway in SKDYS. The findings in this study can provide strong clinical basis for following basic research. Methods A total of 105 patients with SKDYS admitted to the hospital from February 2021 to January 2023 were divided into control group receiving external application of fluoxetine (n=35) and observation group receiving external application of Ruyi Golden Powder (n=70) according the treatment method. Clinical efficacy of control and observation group was compared. Also, extent of redness and swelling, pain score, white blood cell level, neutrophil percentage, serum NLRP1, serum Caspase-1, and serum IL-1β and serum IL-18 of the two group before and after a 21-days of treatment were compared. Results Compared with before treatment, after 21 days of treatment both of two groups showed the significant decrease of the extent of redness and swelling, pain scores, white blood cell levels, neutrophil percentage, serum IL-1β, serum IL-18, serum NLRP1 and serum Caspase-1. After 21 days of treatment, compared with control group, observation group developed an increase in clinical efficacy, and the decreases in the extent of redness and swelling, pain score, white blood cell level, neutrophil percentage, and serum IL-1β, serum IL-18, serum NLRP1 and serum Caspase-1. Conclusion Ruyi Golden Powder effectively improved redness and selling and heat and pain of patients with SKDYS, and significantly inhibited the inflammatory response and NLRP1/Caspase-1 pathway in these patients. This study suggests the potential mechanism of Ruyi Golden Powder in treating SKDYS based on the NLRP1/Capase-1 pathway, providing a strong preliminary basis for following basic experiments.

Key words： skin and external diseases with Yang syndrome Ruyi Golden powder NLPR1 caspase-1

收稿日期: 2024-01-01

中图分类号:

R26

基金资助:湖南省中医药管理局一般项目“基于 PRR/NLRP1/IL-1β通路介导细胞焦亡探讨如意金黄散对阳证疮疡的作用机制”（B2023130）

通讯作者: 宋晓玲,E-mail：316481890@qq.com

引用本文:

郭维, 向丽萍, 宋晓玲. 如意金黄散在阳证疮疡中的抗炎作用及对NLRP1/Caspase-1通路的影响[J]. 湖南师范大学学报(医学版), 2024, 21(3): 63-68. GUO Wei, XIANG Liping, SONG Xiaoling. The anti-inflammatory role of Ruyi golden powder in skin and external diseases with Yang syndrome and its impact on NLRP1/Caspase-1 pathway. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 63-68.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I3/63

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